Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 4/20 | 0.44 |
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | NOS2 | P35228 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.41 |
| ▸ | HTR3B | O95264 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5609745 | 0.76 | ACHE (0.44) | NOS3NOS1NOS2CYP2A6HTR3E | |
| SCHEMBL98201 | 0.74 | NOS3 (0.45) | NOS3NOS1NOS2LMNACYP2D6 | |
| SCHEMBL6385307 | 0.74 | NOS3 (0.44) | NOS3NOS1LMNASLC22A2SLC22A1 | |
| SCHEMBL4607389 | 0.74 | NOS1 (0.44) | NOS1CYP2A6SLC22A2SLC22A1SLC22A3 | |
| SCHEMBL8767212 | 0.74 | PLAU (0.52) | LMNACYP2A6PLAUTDP1ALDH1A1 | |
| 1,4-Dichlorobenzene SCHEMBL27808925 | 0.73 | LMNA (0.67) | LMNACYP2A6IDO1SLC6A2SLC6A3 | |
| SCHEMBL53706 | 0.72 | — | — | |
| SCHEMBL10990336 | 0.72 | LMNA (0.40) | NOS3NOS1NOS2LMNACYP2A6 | |
| SCHEMBL11214729 | 0.72 | NOS3 (0.51) | NOS3NOS1NOS2LMNAHTR3E | |
| SCHEMBL7790448 | 0.70 | HTR3A (0.43) | NOS3NOS1NOS2LMNACYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113512029-A | Preparation and application of substituted pyrazole compound containing pyrimidinamine | 沈阳中化农药化工研发有限公司 | 2021-10-19 | — | — | CN | claimed |
| US-7674907-B2 | Furanopyridine derivatives and methods of use | AMGEN INC. (US) | 2010-03-09 | — | — | US | claimed |
| EP-1412328-B1 | DOLASTATIN 10 DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-10-04 | — | — | EP | claimed |
| US-20060046977-A1 | Furanopyridine derivatives and methods of use | AMGEN INC. | 2006-03-02 | — | — | US | claimed |
| CN-1553897-A | Dolastatin 10 derivatives | - | 2004-12-08 | — | — | CN | claimed |
| US-6737409-B2 | FOR CANCER THERAPY | HOFFMANN-LA ROCHE INC. | 2004-05-18 | — | — | US | claimed |
| US-20030055002-A1 | Dolastatin 10 derivatives | HOFFMANN-LA ROCHE INC. | 2003-03-20 | — | — | US | claimed |
| US-5439874-A | Preemergence, postemergence herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | claimed |
| EP-0208404-B1 | BENZOTHIAZINE DIOXIDE DERIVATIVES | PFIZER INC. (US) | 1990-08-29 | — | — | EP | claimed |
| EP-0208404-A2 | Benzothiazine dioxide derivatives | PFIZER INC. (US) | 1987-01-14 | — | — | EP | claimed |
| US-4634448-A | CATIONIC TRIAZINE DYES | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1987-01-06 | — | — | US | claimed |
| US-4623486-A | [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity | PFIZER INC. (US) | 1986-11-18 | — | — | US | claimed |
| CN-113512029-B | Preparation and application of substituted pyrazole compound containing pyrimidinamine | 沈阳中化农药化工研发有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-113512029-A | Preparation and application of substituted pyrazole compound containing pyrimidinamine | 沈阳中化农药化工研发有限公司 | 2021-10-19 | — | — | CN | disclosed |
| WO-2019016385-A1 | BENZAMIDE COMPOUNDS AND THEIR USE AS HERBICIDES | BASF SE (DE) | 2019-01-24 | — | — | WO | disclosed |
| US-8759584-B2 | Synthesis of biguanidines and triazines, and biguanidino-aluminium complexes as intermediates | BAYER CROPSCIENCE AG (DE) | 2014-06-24 | — | — | US | disclosed |
| US-4634448-A | CATIONIC TRIAZINE DYES | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1987-01-06 | — | — | US | disclosed |
| US-4623486-A | [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity | PFIZER INC. (US) | 1986-11-18 | — | — | US | disclosed |
| US-4453945-A | Process for dyeing cellulose fibers of its union fibers with reactive triazinyl dye quaternized with nicotinic acid | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1984-06-12 | — | — | US | disclosed |
| US-4220356-A | Recording materials containing chromenoindoles | FUJI PHOTO FILM CO., LTD. (JP) | 1980-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060046977-A1 | Furanopyridine derivatives and methods of use | LCK, NFATC1, MINK1 | NOS3 857/4885NOS1 210/4885NOS2 769/4885 |
| US-20030055002-A1 | Dolastatin 10 derivatives | DAD1, DDOST, NPC1 | NOS3 2959/4885NOS1 2592/4885NOS2 3259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.