Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.43 |
| ▸ | HTR3B | O95264 | 3/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.43 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.43 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 4/20 | 0.37 |
| ▸ | NOS1 | P29475 | 4/20 | 0.37 |
| ▸ | NOS2 | P35228 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5490413 | 0.87 | ADRA2A (0.32) | NOS3NOS1ADRA2AADRA2BADRA2C | |
| SCHEMBL7794049 | 0.85 | HTR3A (0.39) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL10990336 | 0.78 | LMNA (0.40) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7789999 | 0.76 | HTR3E (0.43) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL1720891 | 0.75 | ALDH1A1 (0.41) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL8696375 | 0.74 | HTR3E (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL1735291 | 0.70 | NOS3 (0.44) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7840304 | 0.66 | ALDH1A1 (0.33) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3282366 | 0.64 | LMNA (0.57) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3282369 | 0.64 | LMNA (0.57) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |
| US-H533-H | 1H-PYRAZOLO(1,5-B)OR(5,1-C)-1,2,4-TRIAZOLE MAGENTA COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1988-10-04 | — | — | US | disclosed |
| US-4256896-A | THIAZOLE, IMIDAZOLINE, AND OXAZOLINE DYES; DISPERSE DYES; ANIONIC DYES; TEXTILES | CIBA-GEIGY AKTIENGESELLSCHAFT (DE) | 1981-03-17 | — | — | US | disclosed |
| US-4246422-A | Naphtholactam dyestuffs | CIBA-GEIGY AG (CH) | 1981-01-20 | — | — | US | disclosed |
| US-4246410-A | BENZINDOLE DYES OF YELLOW AND RED | CIBA -GEIGY AKTIENGESELLSCHAFT (CH) | 1981-01-20 | — | — | US | disclosed |
| US-4236007-A | YELLOW SHADES ON POLYESTERS | CIBA-GEIGY AKTIENGESELLSCHAFT (CH) | 1980-11-25 | — | — | US | disclosed |
| US-4180665-A | Substituted 3-benz(cd)indol-2-(1H)-ylidene-furo[2,3-b]quinoxalin-2(3H)one dyestuffs | CIBA-GEIGY AKTIENGESELLSCHAFT (CH) | 1979-12-25 | — | — | US | disclosed |
| US-4148805-A | POLYESTERS, RED, YELLLOW | CIBA-GEIGY AG (CH) | 1979-04-10 | — | — | US | disclosed |
| US-4146541-A | YELLOW SHADE ON POLYESTERS | CIBA-GEIGY AG (CH) | 1979-03-27 | — | — | US | disclosed |