Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398026 | 0.85 | ITK (0.48) | ACVR1PAK4HTR6KMT2ALMNA | |
| SCHEMBL17398072 | 0.79 | ITK (0.47) | WDR5ACVR1PAK4HTR6ITK | |
| SCHEMBL17398031 | 0.78 | KDM4E (0.44) | KMT2ALMNAGAA | |
| SCHEMBL17397982 | 0.74 | ALDH1A1 (0.43) | HTR6KMT2ALMNA | |
| SCHEMBL17397937 | 0.72 | HTR6 (0.43) | HTR6KMT2AGAA | |
| SCHEMBL17398060 | 0.71 | AURKA (0.46) | ACVR1PAK4CDK7 | |
| SCHEMBL17398018 | 0.70 | MAPT (0.44) | PAK4LMNAGAA | |
| SCHEMBL17397958 | 0.70 | ITK (0.46) | HTR6KMT2ALMNAITKCDK7 | |
| SCHEMBL20589975 | 0.69 | ACVR1 (0.61) | WDR5ACVR1PAK4KMT2ANPY5R | |
| SCHEMBL31095453 | 0.69 | ACVR1 (0.61) | WDR5ACVR1PAK4KMT2ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |