Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.56 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | ACLY | P53396 | 2/20 | 0.45 |
| ▸ | ACACA | Q13085 | 2/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 6/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599781 | 1.00 | HSD11B1 (0.56) | HSD11B1HSD11B2PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL9618055 | 0.87 | CRYAB (0.46) | HSD11B1HSD11B2PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL1874653 | 0.85 | ACLY (0.48) | HSD11B1HSD11B2PRKAG1PRKAA2PRKAB1 | |
| 3Beta,24,25-Trihydroxycycloartane SCHEMBL3306653 | 0.84 | HSD11B1 (0.76) | HSD11B1HSD11B2PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL568813 | 0.82 | HSD11B1 (0.50) | HSD11B1HSD11B2ACLYACACAPTPN11 | |
| SCHEMBL16411312 | 0.81 | ACLY (0.61) | HSD11B1HSD11B2ACHEACLYACACA | |
| SCHEMBL13642588 | 0.78 | HSD11B1 (0.62) | HSD11B1HSD11B2PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL13642319 | 0.78 | HSD11B1 (0.62) | HSD11B1HSD11B2PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL5824299 | 0.76 | HSD11B1 (0.61) | HSD11B1HSD11B2PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL14046872 | 0.73 | HSD11B1 (0.63) | HSD11B1HSD11B2ACLYACACAPTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1930014-B1 | AGENT FOR AMELIORATION OF INSULIN RESISTANCE | MORINAGA MILK INDUSTRY CO LTD (JP) | 2017-03-01 | — | — | EP | disclosed |
| EP-1930341-B1 | AGENT FOR AMELIORATION OF INSULIN RESISTANCE | MORINAGA MILK INDUSTRY CO LTD (JP) | 2016-04-27 | — | — | EP | disclosed |
| US-8575142-B2 | Agent for improving insulin resistance | MORINAGA MILK INDUSTRY CO., LTD. (JP) | 2013-11-05 | — | — | US | disclosed |
| US-8236769-B2 | Agent for improving insulin resistance | MORINAGA MILK INDUSTRY CO., LTD. (JP) | 2012-08-07 | — | — | US | disclosed |
| US-7947669-B2 | Agent for improving insulin resistance | MORINAGA MILK INDUSTRY CO., LTD. (JP) | 2011-05-24 | — | — | US | disclosed |
| US-20100035851-A1 | AGENT FOR IMPROVING INSULIN RESISTANCE | MORINAGA MILK INDUSTRY CO., LTD (JP) | 2010-02-11 | — | — | US | disclosed |
| US-20090312275-A1 | AGENT FOR IMPROVING INSULIN RESISTANCE | MORINAGA MILK INDUSTRY CO., LTD. (JP) | 2009-12-17 | — | — | US | disclosed |
| US-20090131388-A1 | Agent for Improving Insulin Resistance | MORINAGA MILK INDUSTRY CO., LTD. (JP) | 2009-05-21 | — | — | US | disclosed |
| EP-1930013-A1 | AGENT FOR AMELIORATION OF INSULIN RESISTANCE | Morinaga Milk Industry Co., Ltd. (JP) | 2008-06-11 | — | — | EP | disclosed |
| EP-1930341-A1 | AGENT FOR AMELIORATION OF INSULIN RESISTANCE | Morinaga Milk Industry Co., Ltd. (JP) | 2008-06-11 | — | — | EP | disclosed |
| EP-1930014-A1 | AGENT FOR AMELIORATION OF INSULIN RESISTANCE | Morinaga Milk Industry Co., Ltd. (JP) | 2008-06-11 | — | — | EP | disclosed |
| JP-2005068132-A | ADIPONECTIN SECRETION PROMOTER, AND ANTI-ARTERIOSCLEROSIS AGENT, ANTI-OBESITY AGENT, ANTIDIABETIC MELLITUS AGENT, FOOD ADDITIVE, FUNCTIONAL FOOD AND FEED ADDITIVE CONTAINING ADIPONECTIN SECRETION PROMOTER | ENKAKU IRYO KENKYUSHO:KK | 2005-03-17 | — | — | JP | disclosed |
| JP-2004175679-A | ANTIMICROBIAL AGENT COMPRISING TRITERPENE ALCOHOL AS ACTIVE INGREDIENT | UNIV NIHON | 2004-06-24 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035851-A1 | AGENT FOR IMPROVING INSULIN RESISTANCE | GPR119, IRS1, LIPE | HSD11B1 81/4885HSD11B2 121/4885PRKAG1 1562/4885 |
| US-20090131388-A1 | Agent for Improving Insulin Resistance | GPR119, FABP4, LIPE | HSD11B1 151/4885HSD11B2 166/4885PRKAG1 1450/4885 |
| US-20090312275-A1 | AGENT FOR IMPROVING INSULIN RESISTANCE | GPR119, LIPE, FABP4 | HSD11B1 82/4885HSD11B2 79/4885PRKAG1 797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.