Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | CRYAA | P02489 | 1/20 | 0.40 |
| ▸ | CRYAB | P02511 | 1/20 | 0.40 |
| ▸ | EBP | Q15125 | 2/20 | 0.40 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28831684 | 0.87 | HMGCR (0.54) | HMGCRACLYACACAUSP2LMNA | |
| SCHEMBL16488039 | 0.85 | SLC10A1 (0.42) | HMGCRPTPN1TOP2ACES2CES1 | |
| SCHEMBL15233192 | 0.85 | SLC10A1 (0.42) | HMGCRPTPN1TOP2ACES2CES1 | |
| SCHEMBL24285051 | 0.83 | ACLY (0.54) | HMGCRPTPN1TOP2ACES2CES1 | |
| SCHEMBL17431782 | 0.82 | HSD11B1 (0.55) | HMGCRPTPN1TOP2AACLYACACA | |
| SCHEMBL3479594 | 0.79 | ACLY (0.65) | HMGCRACLYACACAHIF1AUSP2 | |
| SCHEMBL3479596 | 0.79 | ACLY (0.65) | HMGCRACLYACACAHIF1AUSP2 | |
| SCHEMBL4105049 | 0.74 | PTGS2 (0.47) | HMGCRPTPN1ACLYACACALMNA | |
| SCHEMBL9766747 | 0.73 | HMGCR (0.49) | HMGCRPTPN1ACLYACACAHIF1A | |
| SCHEMBL9766753 | 0.73 | HMGCR (0.49) | HMGCRPTPN1ACLYACACAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221690-A1 | Pharmaceutical Composition for the Prevention/Treatment of Bone Disorders and a Process for the Preparation Thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (US) | 2009-09-03 | — | — | US | disclosed |
| EP-1993579-A2 | A PHARMACEUTICAL COMPOSITION FOR THE PREVENTION/TREATMENT OF BONE DISORDERS AND A PROCESS FOR THE PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2008-11-26 | — | — | EP | disclosed |
| EP-1883453-A1 | A PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2008-02-06 | — | — | EP | disclosed |
| WO-2007099432-A2 | PHARMACEUTICAL COMPOSITION CONTAINING BUTEA ISOFLAVONES FOR THE PREVENTION /TREATMENT OF BONE DISORDERS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-09-07 | — | — | WO | disclosed |
| US-20060280817-A1 | Pharmaceutical composition useful for the treatment of hepatocellular carcinoma | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-12-14 | — | — | US | disclosed |
| WO-2006126067-A1 | A PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221690-A1 | Pharmaceutical Composition for the Prevention/Treatment of Bone Disorders and a Process for the Preparation Thereof | SOST, BPGM, PTMS | HMGCR 48/4885PTPN1 2716/4885TOP2A 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.