Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599312 | 0.81 | KEAP1 (0.61) | KMT2AMCL1METAP2MEN1GAA | |
| SCHEMBL788574 | 0.80 | PFKFB4 (0.60) | PFKFB4KMT2AKITMEN1PFKFB3 | |
| SCHEMBL17599407 | 0.79 | ACLY (0.58) | PFKFB4KMT2AMCL1MEN1KDM4E | |
| SCHEMBL17613332 | 0.79 | SERPINE1 (0.36) | KMT2AKDM4ENPSR1 | |
| SCHEMBL17599337 | 0.79 | PTK2B (0.50) | KMT2AMEN1GAAG6PDMAP1LC3B | |
| SCHEMBL17599343 | 0.78 | KEAP1 (0.46) | PFKFB4KMT2AMCL1KITBRD4 | |
| SCHEMBL17599376 | 0.77 | FABP4 (0.56) | KMT2AMEN1GAAG6PDMAP1LC3B | |
| SCHEMBL17599390 | 0.77 | KEAP1 (0.56) | PFKFB4KMT2AMCL1BRD4KDM4E | |
| SCHEMBL17599362 | 0.76 | KMT2A (0.46) | KMT2AMCL1MEN1GAAG6PD | |
| SCHEMBL17599401 | 0.76 | PFKFB4 (0.69) | PFKFB4NPSR1PFKFB3KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |