Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 8/20 | 0.41 |
| ▸ | CA1 known ✓ | P00915 | 7/20 | 0.41 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL17835788 | 0.96 | CA2 (0.41) | CA2CA1MMP1MMP2MMP9 | |
| Sulfuric Acid SCHEMBL19739058 | 0.74 | CA2 (0.55) | CA2CA1MMP1MMP2MMP9 | |
| Perflubutane SCHEMBL19739067 | 0.71 | CA2 (0.50) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL3366661 | 0.70 | THRB (0.56) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL19811134 | 0.70 | CA2 (0.58) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL4871654 | 0.70 | THRB (0.56) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL2368073 | 0.70 | THRB (0.56) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL814004 | 0.70 | CA2 (0.58) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL866860 | 0.70 | CA2 (0.58) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL151831 | 0.70 | THRB (0.56) | CA2CA1MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034532-B1 | POLYORGANOSILOXANE-CONTAINING GRAFT COPOLYMER, RESIN COMPOSITION, MOLDED ARTICLE, SLIDING-PROPERTIES IMPROVEMENT AGENT, AND SLIDING MEMBER | MITSUBISHI CHEM CORP (JP) | 2019-11-06 | — | — | EP | disclosed |
| EP-3375800-A1 | POLYORGANOSILOXANE-CONTAINING GRAFT COPOLYMER, RESIN COMPOSITION, MOLDED ARTICLE, SLIDING-PROPERTIES IMPROVEMENT AGENT, AND SLIDING MEMBER | Mitsubishi Chemical Corporation (JP) | 2018-09-19 | — | — | EP | disclosed |
| US-9765170-B2 | Graft copolymer containing polyorganosiloxane, resin composition, molded article, slidability-improving agent, and sliding member | MITSUBISHI CHEMICAL CORPORATION (JP) | 2017-09-19 | — | — | US | disclosed |
| US-20160194428-A1 | GRAFT COPOLYMER CONTAINING POLYORGANOSILOXANE, RESIN COMPOSITION, MOLDED ARTICLE, SLIDABILITY-IMPROVING AGENT, AND SLIDING MEMBER | MITSUBISHI RAYON CO., LTD. (JP) | 2016-07-07 | — | — | US | disclosed |
| EP-3034532-A2 | POLYORGANOSILOXANE-CONTAINING GRAFT COPOLYMER, RESIN COMPOSITION, MOLDED ARTICLE, SLIDING-PROPERTIES IMPROVEMENT AGENT, AND SLIDING MEMBER | Mitsubishi Rayon Co., Ltd. (JP) | 2016-06-22 | — | — | EP | disclosed |