SCHEMBL17894166

SCHEMBL17894166

CC(O)C(c1ccc(C#C[Si](C)(C)C)cc1)c1ccc(C#C[Si](C)(C)C)cc1

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.33
ACACB O00763 6/20 0.31
GABRA1 P14867 1/20 0.30
GABRG2 P18507 1/20 0.30
GABRB3 P28472 1/20 0.30
GABRA5 P31644 1/20 0.30
GABRA3 P34903 1/20 0.30
GABRA2 P47869 1/20 0.30
GPX4 P36969 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17894164 1.00 FFAR1 (0.33) FFAR1ACACBGABRA1GABRG2GABRB3
SCHEMBL23977506 0.85 NOS3 (0.40) FFAR1ACACBGABRA1GABRG2GABRB3
SCHEMBL28977400 0.85 NOS3 (0.40) FFAR1ACACBGABRA1GABRG2GABRB3
SCHEMBL8129656 0.80 ACACB (0.39) FFAR1ACACBGABRA1GABRG2GABRB3
SCHEMBL17464783 0.79 ACACB (0.41) FFAR1ACACB
SCHEMBL17464776 0.79 ACACB (0.41) FFAR1ACACB
SCHEMBL30200615 0.77 ADRB2 (0.43) FFAR1GABRA1GABRG2GABRB3GABRA5
SCHEMBL21673923 0.77 ADRB2 (0.43) FFAR1GABRA1GABRG2GABRB3GABRA5
SCHEMBL1306384 0.77 GABRA1 (0.38) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL20695038 0.76 TSHR (0.37) FFAR1ACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240423207-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY CORTEVA AGRISCIENCE LLC (US) 2024-12-26 US disclosed
US-12114660-B2 Picolinamide compounds with fungicidal activity CORTEVA AGRISCIENCE LLC (US) 2024-10-15 US disclosed
US-20230371516-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY CORTEVA AGRISCIENCE LLC (US) 2023-11-23 US disclosed
US-11751568-B2 Picolinamide compounds with fungicidal activity CORTEVA AGRISCIENCE LLC (US) 2023-09-12 US disclosed
US-20220159962-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY CORTEVA AGRISCIENCE LLC (US) 2022-05-26 US disclosed
US-11284620-B2 Picolinamide compounds with fungicidal activity CORTEVA AGRISCIENCE LLC (US) 2022-03-29 US disclosed
EP-3808181-A1 USE OF PICOLINAMIDE COMPOUNDS AS FUNGICIDES Dow AgroSciences LLC (US) 2021-04-21 EP disclosed
EP-3240773-B9 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY DOW AGROSCIENCES LLC (US) 2021-01-13 EP disclosed
EP-3240424-B1 USE OF PICOLINAMIDE COMPOUNDS AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2020-09-16 EP disclosed
EP-3240773-B1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY DOW AGROSCIENCES LLC (US) 2020-06-03 EP disclosed
US-20200120936-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY CORTEVA AGRISCIENCE LLC 2020-04-23 US disclosed
US-10595531-B2 Use of picolinamide compounds as fungicides DOW AGROSCIENCES LLC (US) 2020-03-24 US disclosed
US-10588318-B2 Picolinamide compounds with fungicidal activity DOW AGROSCIENCES LLC (US) 2020-03-17 US disclosed
US-10182568-B2 Use of picolinamide compounds as fungicides DOW AGROSCIENCES LLC (US) 2019-01-22 US disclosed
EP-3240773-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY Dow AgroSciences LLC (US) 2017-11-08 EP disclosed
EP-3240424-A1 USE OF PICOLINAMIDE COMPOUNDS AS FUNGICIDES Dow AgroSciences LLC (US) 2017-11-08 EP disclosed
US-20170295792-A1 USE OF PICOLINAMIDE COMPOUNDS AS FUNGICIDES CORTEVA AGRISCIENCE LLC 2017-10-19 US disclosed
US-20170290333-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY CORTEVA AGRISCIENCE LLC 2017-10-12 US disclosed
WO-2016122802-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY DOW AGROSCIENCES LLC (US) 2016-08-04 WO disclosed
WO-2016109257-A1 USE OF PICOLINAMIDE COMPOUNDS AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2016-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10595531-B2 Use of picolinamide compounds as fungicides PFAS, FKBP2, FKBP14 FFAR1 821/4885ACACB 3130/4885GABRA1 1035/4885
US-20170290333-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY PFAS, CASP2, CYP1A2 FFAR1 863/4885ACACB 2570/4885GABRA1 1574/4885
US-10182568-B2 Use of picolinamide compounds as fungicides PFAS, FKBP2, FKBP14 FFAR1 821/4885ACACB 3130/4885GABRA1 1035/4885
US-20220159962-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY PFAS, CASP2, CYP1A2 FFAR1 863/4885ACACB 2570/4885GABRA1 1574/4885
US-20170295792-A1 USE OF PICOLINAMIDE COMPOUNDS AS FUNGICIDES PFAS, FKBP2, FKBP14 FFAR1 821/4885ACACB 3130/4885GABRA1 1035/4885
US-20200120936-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY PFAS, CASP2, CYP1A2 FFAR1 863/4885ACACB 2570/4885GABRA1 1574/4885
US-20230371516-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY PFAS, CASP2, CYP1A2 FFAR1 863/4885ACACB 2570/4885GABRA1 1574/4885
US-11751568-B2 Picolinamide compounds with fungicidal activity PFAS, CASP2, CYP1A2 FFAR1 863/4885ACACB 2570/4885GABRA1 1574/4885
US-12114660-B2 Picolinamide compounds with fungicidal activity PFAS, CASP2, CYP1A2 FFAR1 863/4885ACACB 2570/4885GABRA1 1574/4885
US-11284620-B2 Picolinamide compounds with fungicidal activity PFAS, CASP2, CYP1A2 FFAR1 863/4885ACACB 2570/4885GABRA1 1574/4885
US-10588318-B2 Picolinamide compounds with fungicidal activity PFAS, CASP2, CYP1A2 FFAR1 863/4885ACACB 2570/4885GABRA1 1574/4885
US-20240423207-A1 PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY PFAS, CASP2, CYP1A2 FFAR1 863/4885ACACB 2570/4885GABRA1 1574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.