Benzene

Benzene

SCHEMBL180753

O=S(=O)([O-])NCl.[Na+].c1ccccc1

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CA12 known ✓ O43570 2/20 0.36
CA2 known ✓ P00918 2/20 0.36
CA9 Q16790 2/20 0.36
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL630833 0.97 CA12 (0.34) CA12CA2CA9MEN1ALDH1A1
SCHEMBL10445874 0.89
Lithium Ion SCHEMBL21753847 0.82
Potassium Ion SCHEMBL21753862 0.82
Toluene SCHEMBL7188331 0.81 LMNA (0.48) CA12CA2CA9MEN1ALDH1A1
Benzene SCHEMBL6886142 0.73 TSHR (0.46) CA12CA2CA9MEN1ALDH1A1
Benzene SCHEMBL1584200 0.73 TSHR (0.46) CA12CA2CA9MEN1ALDH1A1
Benzene SCHEMBL3130121 0.69 TSHR (0.36) CA2ALDH1A1TSHR
Benzene SCHEMBL7603410 0.69 CA1 (0.43) CA12CA2CA9ALDH1A1
Benzene SCHEMBL5664348 0.67 MEN1 (0.40) CA12CA2CA9MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 195 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2401001-A1 ANTI- INFECTIVE FUNCTIONALIZED SURFACES AND METHODS OF MAKING SAME Orthobond Corp. (US) 2012-01-04 EP claimed
WO-2010099221-A1 ANTI- INFECTIVE FUNCTIONALIZED SURFACES AND METHODS OF MAKING SAME ORTHOBOND CORP. (US) 2010-09-02 WO claimed
US-20100215643-A1 ANTI-INFECTIVE FUNCTIONALIZED SURFACES AND METHODS OF MAKING SAME ORTHOBOND CORP. (US) 2010-08-26 US claimed
US-4565787-A N-HALOGENO-N-METAL ARYSULFONAMIDATES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1986-01-21 US claimed
JP-54060352-A None JP disclosed
US-20240141370-A1 AGRICULTURAL COMPOSITIONS AND RELATED METHODS FLAGSHIP PIONEERING INNOVATIONS VI LLC (US) 2024-05-02 US disclosed
EP-4355890-A1 MODIFICATION OF PLANT MESSENGER PACKS Flagship Pioneering Innovations VI, LLC (US) 2024-04-24 EP disclosed
EP-2865743-B1 Improvements in dispensing devices RECKITT BENCKISER LLC (US) 2024-03-27 EP disclosed
WO-2024046834-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS ANALYTICON DISCOVERY GMBH (DE) 2024-03-07 WO disclosed
EP-4331564-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS Analyticon Discovery GmbH (DE) 2024-03-06 EP disclosed
US-11827897-B2 Agricultural compositions and related methods FLAGSHIP PIONEERING INNOVATIONS VI, LLC (US) 2023-11-28 US disclosed
WO-2023096858-A1 A BACTERIA-DERIVED LIPID COMPOSITION AND USE THEREOF SENDA BIOSCIENCES, INC. (US) 2023-06-01 WO disclosed
EP-1961301-A1 Biocide compositions comprising a dialkylamide of a hydroxycarboxylic acid Cognis IP Management GmbH (DE) 2008-08-27 EP disclosed
EP-1961302-A1 Biocide compositions comprising at least one dialkylamide based on oleic or linoleic acid Cognis IP Management GmbH (DE) 2008-08-27 EP disclosed
WO-2007107769-A1 IMPROVEMENTS IN LAVATORY DISPENSING DEVICES RECKITT BENCKISER INC. (US) 2007-09-27 WO disclosed
US-6245361-B1 APPLYING SURFACE AN AQUEOUS SOLUTION OF A SYNERGISTIC MIXTURE OF CHLORINE BLEACH AND BACTERICIDE S. C. JOHNSON COMMERCIAL MARKETS, INC. 2001-06-12 US disclosed
EP-0844827-B1 TUBERCULOCIDAL SYNERGISTIC DISINFECTANT COMPOSITIONS AND METHODS OF DISINFECTING JOHNSON S C COMM MARKETS INC (US) 1999-06-09 EP disclosed
US-4565787-A N-HALOGENO-N-METAL ARYSULFONAMIDATES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1986-01-21 US disclosed
JP-S5460352-A POLYCARBONATE RESIN COMPOSITION TEIJIN CHEM LTD 1979-05-15 JP disclosed
US-3943243-A SODIUM BISULFATE, P-DICHLORO-BENZENE OR NAPHTHALENE E. I. DU PONT DE NEMOURS AND CO. (US) 1976-03-09 US disclosed