SCHEMBL180930

SCHEMBL180930

O=C(CI)NCC1CCC(C(=O)ON2C(=O)CCC2=O)CC1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.33
ALDH1A1 P00352 4/20 0.32
CNR1 P21554 1/20 0.32
CNR2 P34972 1/20 0.32
HDAC3 O15379 2/20 0.32
HDAC4 P56524 2/20 0.32
HDAC1 Q13547 2/20 0.32
HDAC7 Q8WUI4 2/20 0.32
HDAC2 Q92769 2/20 0.32
HDAC10 Q969S8 2/20 0.32
HDAC11 Q96DB2 2/20 0.32
HDAC8 Q9BY41 2/20 0.32
HDAC6 Q9UBN7 2/20 0.32
HDAC9 Q9UKV0 2/20 0.32
HDAC5 Q9UQL6 2/20 0.32
KDM4E B2RXH2 2/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25465262 0.80 TGM2 (0.35) TDP1ALDH1A1MGLLMEN1KMT2A
SCHEMBL181071 0.80 FOLH1 (0.37) ALDH1A1CNR1CNR2HPGDHSD17B10
SCHEMBL21538842 0.79 MEN1 (0.33) ALDH1A1HPGDMGLLMEN1KMT2A
SCHEMBL18751703 0.79 MGLL (0.33) TDP1MGLLKMT2ASMN1; SMN2
SCHEMBL17776064 0.79 MGLL (0.33) TDP1MGLLKMT2ASMN1; SMN2
SCHEMBL17776136 0.79 MGLL (0.33) TDP1MGLLKMT2ASMN1; SMN2
SCHEMBL855021 0.79 MGLL (0.33) TDP1MGLLKMT2ASMN1; SMN2
SCHEMBL15289811 0.78 DRD2 (0.48) ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL21731479 0.78 MAP3K7 (0.34) TDP1ALDH1A1HDAC3HDAC4HDAC1
SCHEMBL18297142 0.78 DRD2 (0.48) ALDH1A1MEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 757 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240293524-A1 MULTIPLE FUNCTIONALIZED noMV CONJUGATES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2024-09-05 US claimed
US-11712423-B2 Methods and compositions for modifying mucous membranes ABBOTT NICHOLAS L (US) 2023-08-01 US claimed
US-20230137914-A1 nOMV-ANTIGEN CONJUGATED COMPOUNDS AND USE THEREOF GLAXOSMITHKLINE BIOLOGICALS, S.A. (BE) 2023-05-04 US claimed
US-20220008529-A1 MULTI-FUNCTIONALIZED noMV CONJUGATES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2022-01-13 US claimed
EP-3799883-A1 NOMV-ANTIGEN CONJUGATED COMPOUNDS AND USE THEREOF GlaxoSmithKline Biologicals S.A. (BE) 2021-04-07 EP claimed
EP-3664837-A1 MULTI-FUNCTIONALIZED nOMV CONJUGATES GlaxoSmithKline Biologicals S.A. (BE) 2020-06-17 EP claimed
WO-2019030271-A1 MULTI-FUNCTIONALIZED nOMV CONJUGATES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2019-02-14 WO claimed
US-20180263927-A1 AFFINITY MEDICANT CONJUGATE AF CHEMICALS, LLC (US) 2018-09-20 US claimed
WO-2015017316-A2 METHODS AND COMPOSITIONS FOR MODIFYING MUCOUS MEMBRANES ABBOTT NICHOLAS L (US) 2015-02-05 WO claimed
US-20130183270-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. (US) 2013-07-18 US claimed
EP-2171457-B1 IMPROVEMENTS IN OR RELATING TO PRODUCTION OF CONJUGATES INNOVA BIOSCIENCES LTD (GB) 2013-07-10 EP claimed
US-20120270787-A1 COMPOUNDS HAVING PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2012-10-25 US claimed
CN-101790684-A Improvements in or relating to the preparation of conjugates INNOVA BIOSCIENCES LTD 2010-07-28 CN claimed
US-20100184184-A1 Production of Conjugates INNOVA BIOSCIENCES LIMITED (GB) 2010-07-22 US claimed
EP-2171457-A2 IMPROVEMENTS IN OR RELATING TO PRODUCTION OF CONJUGATES Innova Biosciences Limited (GB) 2010-04-07 EP claimed
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-04-01 US claimed
WO-2008152424-A2 IMPROVEMENTS IN OR RELATING TO PRODUCTION OF CONJUGATES INNOVA BIOSCIENCES LIMITED (GB) 2008-12-18 WO claimed
US-20030148304-A1 Method for immobilisation KAROLINSKA INNOVATIONS AB (SE) 2003-08-07 US claimed
EP-1235937-A1 METHOD FOR IMMOBILISATION Karolinska Innovations AB (SE) 2002-09-04 EP claimed
WO-2001042501-A1 METHOD FOR IMMOBILISATION KAROLINSKA INNOVATIONS AB (SE) 2001-06-14 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120270787-A1 COMPOUNDS HAVING PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF SOST, CALCRL, CALCA TDP1 2295/4885ALDH1A1 4538/4885CNR1 3652/4885
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs FABP2, FABP1, LIPC TDP1 4742/4885ALDH1A1 3404/4885CNR1 1065/4885
US-20230137914-A1 nOMV-ANTIGEN CONJUGATED COMPOUNDS AND USE THEREOF VAPB, CD14, CHMP4B TDP1 4232/4885ALDH1A1 4669/4885CNR1 4654/4885
US-20130183270-A1 Orally Bioavailable Lipid-Based Constructs FABP2, FABP1, LIPC TDP1 4742/4885ALDH1A1 3404/4885CNR1 1065/4885
US-20240293524-A1 MULTIPLE FUNCTIONALIZED noMV CONJUGATES CD14, VAPB, CHMP4B TDP1 4120/4885ALDH1A1 4653/4885CNR1 4593/4885
US-20220008529-A1 MULTI-FUNCTIONALIZED noMV CONJUGATES CD14, CHMP4B, VAPB TDP1 4095/4885ALDH1A1 4555/4885CNR1 4599/4885
US-20180263927-A1 AFFINITY MEDICANT CONJUGATE FCER2, HDGF, FCGR2A TDP1 4547/4885ALDH1A1 3966/4885CNR1 441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.