SCHEMBL18389643

SCHEMBL18389643

C[SiH](C)O[SiH](C)CCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
HPGD P15428 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
CASP1 P29466 1/20 0.39
HSD17B10 Q99714 1/20 0.39
TAAR1 Q96RJ0 3/20 0.39
ATM Q13315 1/20 0.39
TDP1 Q9NUW8 2/20 0.38
CYP2A6 P11509 1/20 0.38
HTR2A P28223 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
LOXL2 Q9Y4K0 1/20 0.38
IDO1 P14902 1/20 0.36
AOC3 Q16853 1/20 0.36
TP53 P04637 1/20 0.36
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL837631 0.81 ALDH1A1 (0.41) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL338863 0.81 ALDH1A1 (0.41) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL3342114 0.78 TP53 (0.39) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL29316305 0.77 SIGMAR1 (0.33) ALDH1A1TAAR1ATMCYP2A6AOC3
SCHEMBL17519998 0.76 ALDH1A1 (0.37) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL476138 0.75 TP53 (0.50) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL7749434 0.75 ALDH1A1 (0.48) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL28914812 0.75 ALDH1A1 (0.35) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL3482599 0.75 IDO1 (0.37) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL28480539 0.73 ADRA1A (0.40) SMN1; SMN2IDO1AOC3MAOAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017010366-A1 HYDROSILYLATION REACTION CATALYST 国立大学法人九州大学 2017-01-19 WO disclosed