Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.66 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31511909 | 1.00 | MEN1 (0.67) | MEN1KMT2AALOX5OR51E2CYP3A4 | |
| SCHEMBL9730692 | 0.92 | MEN1 (0.67) | MEN1KMT2AALOX5OR51E2CYP3A4 | |
| SCHEMBL30129997 | 0.89 | CYP19A1 (0.71) | MEN1KMT2AALOX5OR51E2CYP3A4 | |
| SCHEMBL2292369 | 0.89 | CYP19A1 (0.71) | MEN1KMT2AALOX5OR51E2CYP3A4 | |
| SCHEMBL29535974 | 0.86 | MEN1 (0.70) | MEN1KMT2AALOX5OR51E2CYP3A4 | |
| SCHEMBL1245832 | 0.86 | MEN1 (0.70) | MEN1KMT2AALOX5OR51E2CYP3A4 | |
| SCHEMBL1841125 | 0.85 | ALOX5 (0.63) | MEN1KMT2AALOX5OR51E2CYP3A4 | |
| SCHEMBL4656453 | 0.85 | MEN1 (0.76) | MEN1KMT2ACYP3A4ALDH1A1NPC1 | |
| SCHEMBL31511903 | 0.85 | MEN1 (0.76) | MEN1KMT2ACYP3A4ALDH1A1NPC1 | |
| SCHEMBL1841469 | 0.83 | CYP19A1 (0.80) | MEN1KMT2AALOX5OR51E2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778987-B2 | Use of 4-hydroxychalcone derivatives for masking an unpleasant taste | SYMRISE AG (DE) | 2014-07-15 | — | — | US | claimed |
| EP-1972203-B1 | Use of 4-hydroxychalkon derivatives for masking an unpleasant taste | SYMRISE AG (DE) | 2012-05-16 | — | — | EP | claimed |
| EP-1977655-B1 | Aroma compositions of alkamides with hesperetin and/or 4-hydroxydihydrochalkones and their salts for reinforcing sweet sensory impressions | SYMRISE AG (DE) | 2011-05-18 | — | — | EP | claimed |
| US-20100233102-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2010-09-16 | — | — | US | claimed |
| EP-1998636-B1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO KG (DE) | 2010-05-19 | — | — | EP | claimed |
| EP-1998636-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | Symrise GmbH & Co. KG (DE) | 2008-12-10 | — | — | EP | claimed |
| EP-1977655-A1 | Aroma compositions of alkamides with hesperetin and/or 4-hydroxydihydrochalkones and their salts for reinforcing sweet sensory impressions | Symrise GmbH & Co. KG (DE) | 2008-10-08 | — | — | EP | claimed |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | SYMRISE GMBH & CO. KG (DE) | 2008-10-02 | — | — | US | claimed |
| EP-1972203-A1 | Use of 4-hydroxychalkon derivatives for masking an unpleasant taste | Symrise GmbH & Co. KG (DE) | 2008-09-24 | — | — | EP | claimed |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | claimed |
| WO-2007107596-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2007-09-27 | — | — | WO | claimed |
| US-11759435-B2 | Dihydrochalcone derivatives influencing inflammatory states | SYMRISE AG (DE) | 2023-09-19 | — | — | US | disclosed |
| US-11759435-B2 | Dihydrochalcone derivatives influencing inflammatory states | SYMRISE AG (DE) | 2023-09-19 | — | — | US | disclosed |
| WO-2023278394-A1 | POLYCATIONIC SALTS OF PHENOLIC COMPOUNDS AND USES THEREOF | FIRMENICH INCORPORATED (US) | 2023-01-05 | — | — | WO | disclosed |
| WO-2017186298-A1 | DIHYDROCHALCONE DERIVATIVES INFLUENCING INFLAMMATORY STATES | SYMRISE AG (DE) | 2017-11-02 | — | — | WO | disclosed |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | SYMRISE GMBH & CO. KG (DE) | 2008-09-18 | — | — | US | disclosed |
| WO-2007107596-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2007-09-27 | — | — | WO | disclosed |
| WO-2007107596-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227867-A1 | USE OF 4-HYDROXYCHALCONE DERIVATIVES FOR MASKING AN UPLEASANT TASTE | TAS2R45, TAS2R43, TAS2R30 | MEN1 2094/4885KMT2A 3591/4885ALOX5 386/4885 |
| US-20080242740-A1 | AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS | TAS2R5, TAS2R20, TAS2R40 | MEN1 2488/4885KMT2A 155/4885ALOX5 1963/4885 |
| US-11759435-B2 | Dihydrochalcone derivatives influencing inflammatory states | IL17A, TNF, IL1B | MEN1 4088/4885KMT2A 4463/4885ALOX5 201/4885 |
| US-20100233102-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | TAS2R4, TAS2R1, TAS2R20 | MEN1 1195/4885KMT2A 1660/4885ALOX5 2788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.