Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 7/20 | 0.53 |
| ▸ | NOS1 | P29475 | 6/20 | 0.53 |
| ▸ | NOS3 | P29474 | 5/20 | 0.53 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ARG2 | P78540 | 4/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17381816 | 0.82 | GSR (0.48) | NOS2NOS1NOS3GSRSLC1A3 | |
| SCHEMBL20993880 | 0.82 | GSR (0.48) | NOS2NOS1NOS3GSRSLC1A3 | |
| SCHEMBL126967 | 0.81 | NOS1 (0.56) | NOS2NOS1NOS3GSRCYP2C19 | |
| SCHEMBL23682855 | 0.81 | NOS1 (0.56) | NOS2NOS1NOS3GSRCYP2C19 | |
| SCHEMBL25662318 | 0.81 | NOS1 (0.56) | NOS2NOS1NOS3GSRCYP2C19 | |
| SCHEMBL1527395 | 0.80 | NOS2 (0.65) | NOS2NOS1NOS3GSRSLC1A3 | |
| SCHEMBL25629375 | 0.80 | NOS2 (0.65) | NOS2NOS1NOS3GSRSLC1A3 | |
| SCHEMBL1527394 | 0.80 | NOS2 (0.65) | NOS2NOS1NOS3GSRSLC1A3 | |
| SCHEMBL15592476 | 0.80 | GSR (0.64) | NOS2NOS1NOS3GSRSLC1A3 | |
| SCHEMBL13343952 | 0.80 | GSR (0.64) | NOS2NOS1NOS3GSRSLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786078-B2 | Template-fixed δ-hairpin peptidomimetics with CXCR4 antagonizing activity | POLYPHOR LTD. (CH) | 2010-08-31 | — | — | US | claimed |
| US-10730912-B2 | Template-fixed peptidomimetics with antimicrobial activity | POLYPHOR LTD. (CH) | 2020-08-04 | — | — | US | disclosed |
| US-10562933-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | POLYPHOR LTD. (CH) | 2020-02-18 | — | — | US | disclosed |
| US-20190002498-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY | POLYPHOR LTD (CH) | 2019-01-03 | — | — | US | disclosed |
| US-10100084-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | POLYPHOR LTD. (CH) | 2018-10-16 | — | — | US | disclosed |
| US-10000535-B2 | Template-fixed peptidomimetics | POLYPHOR LTD. (CH) | 2018-06-19 | — | — | US | disclosed |
| US-20170107259-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY | POLYPHOR LTD. (CH) | 2017-04-20 | — | — | US | disclosed |
| US-9596852-B2 | Template-fixed peptidomimetics with antimicrobial activity | POLYPHOR LTD. (CH) | 2017-03-21 | — | — | US | disclosed |
| US-9538752-B2 | Template-fixed peptidomimetics with antimicrobial activity | POLYPHOR LTD. (CH) | 2017-01-10 | — | — | US | disclosed |
| US-9518092-B2 | Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity | POLYPHOR LTD. (CH) | 2016-12-13 | — | — | US | disclosed |
| US-20110245155-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY | POLYPHOR LTD. (CH) | 2011-10-06 | — | — | US | disclosed |
| US-20110230426-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2011-09-22 | — | — | US | disclosed |
| US-20110135576-A1 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS | POLYPHOR LTD. (CH) | 2011-06-09 | — | — | US | disclosed |
| EP-2324047-A2 | TEMPLATE-FIXED PEPTIDOMIMETICS | Polyphor Ag (CH) | 2011-05-25 | — | — | EP | disclosed |
| US-20100240592-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY | POLYPHOR LTD. (CH) | 2010-09-23 | — | — | US | disclosed |
| US-7786078-B2 | Template-fixed δ-hairpin peptidomimetics with CXCR4 antagonizing activity | POLYPHOR LTD. (CH) | 2010-08-31 | — | — | US | disclosed |
| US-20100093644-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS | POLYPHOR LTD. (CH) | 2010-04-15 | — | — | US | disclosed |
| WO-2010015287-A2 | TEMPLATE-FIXED PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2010-02-11 | — | — | WO | disclosed |
| US-20090054345-A1 | Template-Fixed Beta-Hairpin Peptidomimetics With Protease Inhibitory Activity | POLYPHOR LTD. (CH) | 2009-02-26 | — | — | US | disclosed |
| US-20070078079-A1 | Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity | POLYPHOR LTD. (CH) | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078079-A1 | Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity | CXCR4, CXCL12, CCR5 | NOS2 4111/4885NOS1 3944/4885NOS3 4386/4885 |
| US-10100084-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | CTSG, CTRL, PREP | NOS2 4564/4885NOS1 4287/4885NOS3 4360/4885 |
| US-20190002498-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY | CTSG, CTRL, PREP | NOS2 4564/4885NOS1 4287/4885NOS3 4360/4885 |
| US-20110245155-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY | CXCR4, CXCL12, CCR5 | NOS2 4117/4885NOS1 3938/4885NOS3 4386/4885 |
| US-20110135576-A1 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS | CXCR4, CXCL12, CXCR1 | NOS2 4050/4885NOS1 3595/4885NOS3 4147/4885 |
| US-20170107259-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY | POLL, POLM, POLR1C | NOS2 1717/4885NOS1 1201/4885NOS3 2390/4885 |
| US-20110230426-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS | STAT6, NCOA1, UTS2R | NOS2 2930/4885NOS1 2538/4885NOS3 3819/4885 |
| US-20100240592-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY | POLL, POLM, POLR1C | NOS2 1803/4885NOS1 1148/4885NOS3 2499/4885 |
| US-10000535-B2 | Template-fixed peptidomimetics | CCR10, CXCR3, CCR5 | NOS2 4574/4885NOS1 4454/4885NOS3 4496/4885 |
| US-10730912-B2 | Template-fixed peptidomimetics with antimicrobial activity | POLL, POLM, POLR1C | NOS2 1767/4885NOS1 1228/4885NOS3 2431/4885 |
| US-10562933-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | CTSG, CTRL, PREP | NOS2 4564/4885NOS1 4287/4885NOS3 4360/4885 |
| US-20090054345-A1 | Template-Fixed Beta-Hairpin Peptidomimetics With Protease Inhibitory Activity | CTRL, CTSG, CTSZ | NOS2 4522/4885NOS1 4020/4885NOS3 4316/4885 |
| US-20100093644-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS | CCR10, CXCR3, CCR1 | NOS2 4660/4885NOS1 4491/4885NOS3 4562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.