SCHEMBL1853763

SCHEMBL1853763

OC1=NSNc2ccccc21

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.33
TTR P02766 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9934998 0.75 NOS2 (0.32)
SCHEMBL21170617 0.75 ALDH1A1 (0.33)
SCHEMBL21681870 0.75 NOS2 (0.46) IDO1
SCHEMBL9936062 0.75 MAOA (0.31)
SCHEMBL15650452 0.62 NOS2 (0.60) IDO1
SCHEMBL30030411 0.61 IDO1 (0.32) IDO1
SCHEMBL134420 0.61
SCHEMBL343023 0.58 GAA (0.41) IDO1
SCHEMBL1343014 0.57 PDGFRA (0.50)
SCHEMBL8025107 0.57 APAF1 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10570105-B2 Processes and intermediates for making sweet taste enhancers FIRMENICH INCORPORATED (US) 2020-02-25 US disclosed
US-20190263762-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS FIRMENICH INCORPORATED 2019-08-29 US disclosed
US-10308621-B2 Processes and intermediates for making sweet taste enhancers SENOMYX, INC. (US) 2019-06-04 US disclosed
US-20180370931-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS SENOMYX, INC. 2018-12-27 US disclosed
US-10087154-B2 Processes and intermediates for making sweet taste enhancers SENOMYX, INC. (US) 2018-10-02 US disclosed
US-20170327479-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS SENOMYX, INC. 2017-11-16 US disclosed
EP-2323997-B1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS SENOMYX INC (US) 2017-09-06 EP disclosed
US-9732052-B2 Processes and intermediates for making sweet taste enhancers SENOMYX, INC. (US) 2017-08-15 US disclosed
EP-3085699-A2 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS Senomyx, Inc. (US) 2016-10-26 EP disclosed
US-20160289200-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS SENOMYX, INC. 2016-10-06 US disclosed
US-9382196-B2 Processes and intermediates for making sweet taste enhancers SENOMYX, INC. (US) 2016-07-05 US disclosed
US-20140107370-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS SENOMYX, INC. (US) 2014-04-17 US disclosed
US-8586733-B2 Processes and intermediates for making sweet taste enhancers SENOMYX, INC. (US) 2013-11-19 US disclosed
US-20110245494-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS SENOMYX, INC. (US) 2011-10-06 US disclosed
EP-2323997-A2 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS Senomyx, Inc. (US) 2011-05-25 EP disclosed
WO-2010014666-A2 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS SENOMYX, INC. (US) 2010-02-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10308621-B2 Processes and intermediates for making sweet taste enhancers TAS2R40, TAS2R4, TAS2R45 IDO1 4015/4885TTR 2651/4885
US-20140107370-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS TAS2R50, TAS2R30, TAS2R10 IDO1 2993/4885TTR 1666/4885
US-20180370931-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS TAS2R50, TAS2R30, TAS2R10 IDO1 2993/4885TTR 1666/4885
US-20170327479-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS TAS2R50, TAS2R30, TAS2R10 IDO1 2993/4885TTR 1666/4885
US-10087154-B2 Processes and intermediates for making sweet taste enhancers TAS2R50, TAS2R30, TAS2R10 IDO1 2993/4885TTR 1666/4885
US-20160289200-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS TAS2R50, TAS2R30, TAS2R10 IDO1 2993/4885TTR 1666/4885
US-10570105-B2 Processes and intermediates for making sweet taste enhancers TAS2R13, TAS2R10, TAS2R20 IDO1 4172/4885TTR 3674/4885
US-20110245494-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS TAS2R50, TAS2R30, TAS2R10 IDO1 2993/4885TTR 1666/4885
US-20190263762-A1 PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS TAS2R13, TAS2R10, TAS2R20 IDO1 4172/4885TTR 3674/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.