Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18582906 | 1.00 | LPL (0.39) | LPLLIPGCRHBPCRHR2ALDH1A1 | |
| SCHEMBL25280458 | 0.89 | LPL (0.42) | LPLLIPGALDH1A1TDP1AAK1 | |
| SCHEMBL30566094 | 0.89 | LPL (0.42) | LPLLIPGALDH1A1TDP1AAK1 | |
| SCHEMBL25250508 | 0.89 | LPL (0.42) | LPLLIPGALDH1A1TDP1AAK1 | |
| SCHEMBL15283473 | 0.86 | PDK1 (0.40) | LPLLIPGALDH1A1TDP1AAK1 | |
| SCHEMBL17411095 | 0.82 | LPL (0.36) | LPLLIPGALDH1A1TDP1AAK1 | |
| SCHEMBL18582781 | 0.81 | HTR6 (0.48) | LPLLIPGALDH1A1TDP1P4HB | |
| SCHEMBL3033971 | 0.79 | ALDH1A1 (0.45) | LPLLIPGALDH1A1TDP1MAPT | |
| SCHEMBL30110762 | 0.78 | LPL (0.44) | LPLLIPGP4HBAAK1RORC | |
| SCHEMBL31690752 | 0.78 | DGAT1 (0.47) | LPLLIPGTDP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790207-B2 | Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2017-10-17 | — | — | US | disclosed |
| US-9790207-B2 | Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2017-10-17 | — | — | US | disclosed |
| US-9790207-B2 | Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170066746-A1 | Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2017-03-09 | — | — | US | disclosed |
| US-20170066746-A1 | Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2017-03-09 | — | — | US | disclosed |
| US-20170066746-A1 | Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2017-03-09 | — | — | US | disclosed |
| WO-2017039791-A1 | PAN-GENOMIC INHIBITORS OF NS5A PROTEIN ENCODED BY HCV, PHARMACEUTICAL COMPOSITIONS, INTERMEDIATES FOR INHIBITOR SYNTHESIS, AND THEIR SYNTHESIS AND APPLICATION METHODS. | ALLA CHEM, LLC (US) | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066746-A1 | Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods | POLR2A, GTF3C1, SSU72 | LPL 1689/4885LIPG 3406/4885CRHBP 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.