SCHEMBL18640328

SCHEMBL18640328

COC(=O)C=Cc1c[nH]c(=O)[nH]c1=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPYD Q12882 2/20 0.47
ALDH1A1 P00352 3/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
MAPT P10636 2/20 0.43
KDM4E B2RXH2 1/20 0.43
TP53 P04637 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
CYP2C19 P33261 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MAP3K7 O43318 2/20 0.42
TAB1 Q15750 2/20 0.42
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
TYR P14679 1/20 0.40
CA7 P43166 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18640327 1.00 DPYD (0.47) DPYDALDH1A1MEN1KMT2AMAPT
SCHEMBL14405088 0.81 DPYD (0.52) DPYDALDH1A1MAPTKDM4EMAP3K7
SCHEMBL190328 0.81 DPYD (0.59) DPYDALDH1A1MAPTKDM4ECYP1A2
SCHEMBL190329 0.81 DPYD (0.59) DPYDALDH1A1MAPTKDM4ECYP1A2
SCHEMBL17991880 0.77 HCAR2 (0.42) DPYDALDH1A1MEN1KMT2ACYP1A2
SCHEMBL27253388 0.77 DPYD (0.55) DPYDALDH1A1MEN1KMT2AMAPT
SCHEMBL16784515 0.74 MAP3K7 (0.45) ALDH1A1MEN1KMT2AMAPTKDM4E
SCHEMBL6374591 0.73 DPYD (0.59) DPYDALDH1A1MEN1KMT2AMAPT
SCHEMBL933037 0.73 DPYD (0.59) DPYDALDH1A1MAPTGAAATAD2
SCHEMBL6512588 0.73 DPYD (0.59) DPYDALDH1A1MAPTGAAATAD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 302 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026103877-A1 LIPID COMPOUND AND LIPID NANOPARTICLE COMPOSITION 中生复诺健生物科技(上海)有限公司 2026-05-21 WO disclosed
WO-2026106695-A1 TARGETED NANOPARTICLES ENCAPSULATING WATER-SOLUBLE THERAPEUTICS, METHODS OF PRODUCTION, AND USE OPTIMEOS LIFE SCIENCES, INC. (US) 2026-05-21 WO disclosed
WO-2026098357-A1 FREEZE-DRIED NUCLEIC ACID-LOADED LIPID NANOPARTICLE AND RECONSTITUTION METHOD THEREOF KUDO BIOTECHNOLOGY, INC. (US) 2026-05-15 WO disclosed
US-20260130987-A1 VACCINATION AGAINST PNEUMOCCOCAL AND COVID-19 INFECTIONS PFIZER INC. (US) 2026-05-14 US disclosed
WO-2026088119-A1 LIPIDATED TLR7/8 MODULATORS AS ADJUVANTS AND USES THEREOF PFIZER INC. (US) 2026-04-30 WO disclosed
US-20260109977-A1 MODIFIED RNA FOR INCREASING PROTEIN EXPRESSION TRILINK BIOTECHNOLOGIES, LLC (US) 2026-04-23 US disclosed
EP-4728076-A1 METHOD FOR STABILIZING RNA Pfizer Inc. (US) 2026-04-22 EP disclosed
EP-4720094-A1 MUTATED FRAGMENT OF VZV GLYCOPROTEIN E Suzhou Abogen Biosciences Co., Ltd. (CN) 2026-04-08 EP disclosed
US-12594242-B2 Lipid compounds and lipid nanoparticle compositions Suzhou Abogen Biosciences Co., Ltd. (CN) 2026-04-07 US disclosed
US-20260078082-A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS MODERNATX INC (US) 2026-03-19 US disclosed
WO-2017112865-A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS MODERNATX, INC. (US) 2017-06-29 WO disclosed
WO-2017066789-A1 MRNA CAP ANALOGS WITH MODIFIED SUGAR MODERNATX, INC. (US) 2017-04-20 WO disclosed
WO-2017066797-A1 TRINUCLEOTIDE MRNA CAP ANALOGS MODERNATX, INC. (US) 2017-04-20 WO disclosed
WO-2017066782-A1 HYDROPHOBIC MRNA CAP ANALOGS MODERNATX, INC. (US) 2017-04-20 WO disclosed
WO-2017066781-A1 MRNA CAP ANALOGS WITH MODIFIED PHOSPHATE LINKAGE MODERNATX, INC. (US) 2017-04-20 WO disclosed
WO-2017066791-A1 SUGAR SUBSTITUTED MRNA CAP ANALOGS MODERNATX, INC. (US) 2017-04-20 WO disclosed
WO-2017066793-A1 MRNA CAP ANALOGS AND METHODS OF MRNA CAPPING MODERNATX, INC. (US) 2017-04-20 WO disclosed
WO-2017049286-A1 POLYNUCLEOTIDES CONTAINING A MORPHOLINO LINKER MODERNA THERAPEUTICS, INC. (US) 2017-03-23 WO disclosed
WO-2017049275-A2 POLYNUCLEOTIDES CONTAINING A STABILIZING TAIL REGION MODERNA THERAPEUTICS, INC. (US) 2017-03-23 WO disclosed
WO-2017049245-A2 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS MODERNATX, INC. (US) 2017-03-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109977-A1 MODIFIED RNA FOR INCREASING PROTEIN EXPRESSION RNGTT, RNMT, UPF1 DPYD 1676/4885ALDH1A1 4457/4885MEN1 3384/4885
US-20260130987-A1 VACCINATION AGAINST PNEUMOCCOCAL AND COVID-19 INFECTIONS SARS1, CD14, PYCARD DPYD 4125/4885ALDH1A1 4675/4885MEN1 2650/4885
US-12594242-B2 Lipid compounds and lipid nanoparticle compositions NPC1, NPC1L1, PLIN3 DPYD 3574/4885ALDH1A1 4206/4885MEN1 3870/4885
US-20260078082-A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS PHOSPHO1, LIPC, SDCBP DPYD 2943/4885ALDH1A1 4429/4885MEN1 2564/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.