Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 5/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.46 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.46 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8684058 | 0.85 | CA1 (0.48) | CES2CES1ALDH1A1KIF11EPHX2 | |
| SCHEMBL63468 | 0.83 | ALDH1A1 (0.67) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL2092987 | 0.77 | RORC (0.35) | CES2CES1 | |
| SCHEMBL8994533 | 0.77 | PGK1 (0.33) | CES2CES1 | |
| Iodide SCHEMBL29093539 | 0.76 | ALDH1A1 (0.59) | CES2CES1ALDH1A1TSHRKIF11 | |
| Bromide SCHEMBL29093544 | 0.76 | ALDH1A1 (0.59) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL197238 | 0.73 | KIF11 (0.78) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL16626100 | 0.73 | ALDH1A1 (0.56) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL13410633 | 0.73 | KIF11 (0.78) | CES2CES1ALDH1A1TSHRKIF11 | |
| SCHEMBL29914837 | 0.73 | KIF11 (0.78) | CES2CES1ALDH1A1TSHRKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1343 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11987588-B2 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2024-05-21 | — | — | US | claimed |
| EP-3720858-B1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2023-06-07 | — | — | EP | claimed |
| US-20220396579-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2022-12-15 | — | — | US | claimed |
| EP-3867333-B1 | DISUBSTITUTED DIARYLOXYBENZOHETERODIAZOLE COMPOUNDS | ENI SPA (IT) | 2022-09-14 | — | — | EP | claimed |
| CN-107922350-B | Novel benzimidazole compounds and medicinal use thereof | 大日本住友制药株式会社 | 2022-04-19 | — | — | CN | claimed |
| CN-113166138-A | Disubstituted diaryloxybenzoheterodiazole compounds | 艾尼股份公司 | 2021-07-23 | — | — | CN | claimed |
| US-20200390100-A1 | SUBSTITUTED N-HETEROCYCLYL- AND N-HETEROARYL-TETRAHYDROPYRIMIDINONES AND THE SALTS THEREOF, AND THE USE OF SAME AS HERBICIDAL ACTIVE SUBSTANCES | BAYER AG (DE) | 2020-12-17 | — | — | US | claimed |
| US-20200385395-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2020-12-10 | — | — | US | claimed |
| EP-3728214-A1 | SUBSTITUTED N-HETEROCYCLYL- AND N-HETEROARYL-TETRAHYDROPYRIMIDINONES AND THE SALTS THEREOF, AND THE USE OF SAME AS HERBICIDAL ACTIVE SUBSTANCES | Bayer Aktiengesellschaft (DE) | 2020-10-28 | — | — | EP | claimed |
| EP-3720858-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2020-10-14 | — | — | EP | claimed |
| EP-0147052-A2 | Rodenticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-07-03 | — | — | EP | claimed |
| US-4503100-A | 5-PHENYLCARBAMOYLBARBITURIC ACID AND SYNTHETIC PYRETHROID | CIBA-GEIGY CORPORATION (US) | 1985-03-05 | — | — | US | claimed |
| US-4496745-A | Epoxycarbacyclin derivatives, their preparation and use | SANKYO COMPANY, LIMITED (JP) | 1985-01-29 | — | — | US | claimed |
| EP-0105030-A1 | Protectant against moths and beetles | CIBA-GEIGY AG (CH) | 1984-04-04 | — | — | EP | claimed |
| EP-0093976-A1 | 2,4-Dihalogenbenzoyl ureas and thioureas, processes for their preparation and their use as pesticides | BAYER AG (DE) | 1983-11-16 | — | — | EP | claimed |
| US-4415746-A | BRONCHODILATORS; HYPOTENSIVE AND ANTIFERTILITY AGENTS; OXYTOCICS | AMERICAN CYANAMID COMPANY (US) | 1983-11-15 | — | — | US | claimed |
| EP-0013542-B1 | ALPHA-PHENOXY PROPIONIC ACID GAMMA-BUTYROLACTONE ESTERS AND THIOESTERS WITH HERBICIDAL ACTIVITY, THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AS ACTIVE AGENTS AND THEIR USE | CIBA-GEIGY AG (CH) | 1982-06-02 | — | — | EP | claimed |
| US-4231787-A | 4-(TRIFLUOROMETHYLPHENOXY)PHENOXY-PROPANOLS OR ESTERS | ISHIHARA SANGYO KAISHA LTD. (JP) | 1980-11-04 | — | — | US | claimed |
| EP-0013542-A1 | Alpha-phenoxy propionic acid gamma-butyrolactone esters and thioesters with herbicidal activity, their preparation, compositions containing them as active agents and their use | CIBA-GEIGY AG (CH) | 1980-07-23 | — | — | EP | claimed |
| US-4126629-A | FERTILITY CONTROL | MERCK & CO., INC. (US) | 1978-11-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200390100-A1 | SUBSTITUTED N-HETEROCYCLYL- AND N-HETEROARYL-TETRAHYDROPYRIMIDINONES AND THE SALTS THEREOF, AND THE USE OF SAME AS HERBICIDAL ACTIVE SUBSTANCES | DDT, NOTUM, AGPS | CES2 681/4885CES1 1070/4885ALDH1A1 201/4885 |
| US-11987588-B2 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto | ADRB3, ADRB1, ADRB2 | CES2 2696/4885CES1 779/4885ALDH1A1 700/4885 |
| US-20200385395-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ADRB3, ADRB1, ADRB2 | CES2 2558/4885CES1 784/4885ALDH1A1 682/4885 |
| US-20220396579-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ADRB3, ADRB1, ADRB2 | CES2 2558/4885CES1 784/4885ALDH1A1 682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.