SCHEMBL1870041

SCHEMBL1870041

CC(C)Oc1ccc(C#N)cc1C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 4/20 0.50
XDH P47989 6/20 0.47
ALDH1A1 P00352 1/20 0.46
IRAK4 Q9NWZ3 2/20 0.44
KCNH2 Q12809 2/20 0.44
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17293972 0.88 ALDH1A1 (0.50) SLC6A9XDHALDH1A1IRAK4HTT
SCHEMBL20944764 0.85 LMNA (0.48) SLC6A9XDHIRAK4KCNH2
SCHEMBL4634240 0.84 ALDH1A1 (0.46) SLC6A9XDHALDH1A1IRAK4
SCHEMBL14683841 0.84 SLC6A9 (0.52) SLC6A9KCNH2
SCHEMBL15144070 0.84 SLC6A9 (0.52) SLC6A9KCNH2
SCHEMBL15144069 0.84 SLC6A9 (0.52) SLC6A9KCNH2
SCHEMBL16952110 0.84 SLC6A9 (0.44) SLC6A9XDHIRAK4KCNH2
SCHEMBL546183 0.82 AR (0.50) ALDH1A1
SCHEMBL4037723 0.82 HNF4A (0.56) SLC6A9ALDH1A1IRAK4
Hydrochloric Acid SCHEMBL10984138 0.81 AR (0.49) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3406142-B1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS CELGENE INT II SARL (CH) 2020-12-23 EP disclosed
US-10239846-B2 Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis CELGENE INTERNATIONAL II SÀRL (CH) 2019-03-26 US disclosed
EP-3406142-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS Celgene International II Sàrl (CH) 2018-11-28 EP disclosed
CN-105061350-B The sphingosine 1-phosphate receptor modulators and Chiral Synthesis of selectivity 赛尔基因第二国际有限公司 2018-05-29 CN disclosed
US-20170320839-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS RECEPTOS LLC 2017-11-09 US disclosed
US-20170165236-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND COMBINATION THERAPY THEREWITH RECEPTOS LLC 2017-06-15 US disclosed
EP-3062792-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND COMBINATION THERAPY THEREWITH Celgene International II Sarl (CH) 2016-09-07 EP disclosed
US-9388147-B2 Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis Celgene International II Sárl (CH) 2016-07-12 US disclosed
US-20150299149-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS RECEPTOS LLC 2015-10-22 US disclosed
WO-2015066515-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND COMBINATION THERAPY THEREWITH RECEPTOS, INC. (US) 2015-05-07 WO disclosed
US-7220744-B2 Monocyclic substituted phenyl methanones HOFFMAN-LA ROCHE INC. (US) 2007-05-22 US disclosed
US-20060178381-A1 Heterocyclic-substituted phenyl methanones HOFFMANN-LA ROCHE INC. 2006-08-10 US disclosed
US-20060167009-A1 Monocyclic substituted phenyl methanones F. HOFFMANN-LA ROCHE AG (CH) 2006-07-27 US disclosed
WO-2006072436-A1 [4-(HETEROARYL) PIPERAZIN-1-YL]-(2,5-SUBSTITUTED -PHENYL)METHANONE DERIVATIVES AS GLYCINE TRANSPORTER 1 (GLYT-1) INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2006-07-13 WO disclosed
WO-2006072436-A1 [4-(HETEROARYL) PIPERAZIN-1-YL]-(2,5-SUBSTITUTED -PHENYL)METHANONE DERIVATIVES AS GLYCINE TRANSPORTER 1 (GLYT-1) INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2006-07-13 WO disclosed
WO-2006072432-A1 BENZOYL-TETRAHYDROPYRIDINE AS GLYT-1 INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2006-07-13 WO disclosed
US-20060148797-A1 Benzoyl-tetrahydropiperidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 2006-07-06 US disclosed
EP-1656361-A1 PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-05-17 EP disclosed
US-20050209241-A1 Benzoyl-piperazine derivatives HOFFMANN-LA ROCHE INC. 2005-09-22 US disclosed
WO-2005014563-A1 PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-02-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050209241-A1 Benzoyl-piperazine derivatives SLC1A2, SLC18A2, SLC6A7 SLC6A9 82/4885XDH 1547/4885ALDH1A1 1436/4885
US-20150299149-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS S1PR1, S1PR3, S1PR2 SLC6A9 2568/4885XDH 4139/4885ALDH1A1 2233/4885
US-20060178381-A1 Heterocyclic-substituted phenyl methanones CYP2B6, CYP2D6, CYP1A2 SLC6A9 1024/4885XDH 338/4885ALDH1A1 52/4885
US-20170165236-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND COMBINATION THERAPY THEREWITH S1PR1, S1PR2, S1PR4 SLC6A9 4123/4885XDH 4341/4885ALDH1A1 3235/4885
US-20060148797-A1 Benzoyl-tetrahydropiperidine derivatives GRIN2A, HTR5A, BACE1 SLC6A9 844/4885XDH 545/4885ALDH1A1 143/4885
US-20170320839-A1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS S1PR1, S1PR3, S1PR2 SLC6A9 2568/4885XDH 4139/4885ALDH1A1 2233/4885
US-10239846-B2 Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis S1PR1, S1PR3, S1PR2 SLC6A9 2568/4885XDH 4139/4885ALDH1A1 2233/4885
US-20060167009-A1 Monocyclic substituted phenyl methanones SLC1A2, SULT2A1, SLC6A5 SLC6A9 23/4885XDH 234/4885ALDH1A1 744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.