SCHEMBL18808263

SCHEMBL18808263

C=CC(=O)Oc1ccc2c(c1)OC(O)C(c1ccc(OC)cc1)=C2

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 12/20 0.38
NFKB2 Q00653 12/20 0.38
RELA Q04206 12/20 0.38
NR4A2 P43354 1/20 0.37
CA12 O43570 1/20 0.34
CA9 Q16790 1/20 0.34
ALOX5 P09917 1/20 0.34
TGM2 P21980 1/20 0.34
BACE1 P56817 1/20 0.33
THRB P10828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18869323 0.93 THRB (0.36) NFKB1NFKB2RELATHRB
SCHEMBL20342972 0.85 NFKB1 (0.40) NFKB1NFKB2RELANR4A2CA12
SCHEMBL18869471 0.82 MET (0.35) NFKB1NFKB2RELAALOX5THRB
SCHEMBL2182312 0.81 CA2 (0.44) NFKB1NFKB2RELACA12CA9
SCHEMBL18522702 0.79 ELANE (0.39) NFKB1NFKB2RELA
SCHEMBL21475275 0.78 NFKB1 (0.36) NFKB1NFKB2RELA
SCHEMBL18522600 0.77 THRB (0.41) THRB
SCHEMBL24412119 0.77 ALOX5 (0.48) NFKB1NFKB2RELANR4A2CA12
SCHEMBL953280 0.74 NPSR1 (0.47) NFKB1NFKB2RELAALOX5
SCHEMBL21360524 0.73 ALOX5 (0.42) NFKB1NFKB2RELANR4A2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024133363-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2024-06-27 WO disclosed
WO-2023208801-A1 LIQUID-CRYSTAL MEDIUM COMPRISING POLYMERIZABLE COMPOUNDS MERCK PATENT GMBH (DE) 2023-11-02 WO disclosed
WO-2023209049-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-11-02 WO disclosed
WO-2023203043-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-10-26 WO disclosed
EP-3933009-B1 LIQUID CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-08-16 EP disclosed
EP-4056667-B1 LIQUID-CRYSTAL MEDIUM COMPRISING POLYMERIZABLE COMPOUNDS MERCK PATENT GMBH (DE) 2023-08-02 EP disclosed
EP-3839008-B1 LIQUID CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2023-07-26 EP disclosed
WO-2023066953-A1 LIQUID-CRYSTAL MEDIUM COMPRISING POLYMERIZABLE COMPOUNDS MERCK PATENT GMBH (DE) 2023-04-27 WO disclosed
WO-2022003001-A1 LIQUID CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2022-01-06 WO disclosed
EP-3933009-A1 LIQUID CRYSTAL MEDIUM Merck Patent GmbH (DE) 2022-01-05 EP disclosed
EP-3428246-B1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2020-04-15 EP disclosed
EP-3234689-B1 LIGHT MODULATION ELEMENT MERCK PATENT GMBH (DE) 2020-01-29 EP disclosed
US-10457871-B2 Compounds and liquid-crystalline medium MERCK PATENT GMBH (DE) 2019-10-29 US disclosed
EP-3263673-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-10-02 EP disclosed
US-20190185754-A1 LIQUID-CRYSTALLINE MEDIA HAVING HOMEOTROPIC ALIGNMENT MERCK PATENT GMBH (DE) 2019-06-20 US disclosed
US-9963637-B2 Liquid crystal medium MERCK PATENT GMBH (DE) 2018-05-08 US disclosed
EP-3246377-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2017-11-22 EP disclosed
WO-2017097401-A1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2017-06-15 WO disclosed
EP-2628779-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-05-17 EP disclosed
EP-3162875-A1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS Merck Patent GmbH (DE) 2017-05-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10457871-B2 Compounds and liquid-crystalline medium XDH, MLX, CXCR1 NFKB1 1850/4885NFKB2 2475/4885RELA 3417/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.