Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 3/20 | 0.45 |
| ▸ | KLK1 | P06870 | 2/20 | 0.45 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5958350 | 0.83 | CSNK2A1 (0.67) | NPC1RAB9ACSNK2A1TRPA1MAPT | |
| SCHEMBL302204 | 0.82 | CSNK2A1 (0.48) | NPC1RAB9ACSNK2A1MAPTKDM4E | |
| SCHEMBL1758035 | 0.82 | NPC1 (0.56) | NPC1RAB9ACSNK2A1TRPA1TAS1R3 | |
| SCHEMBL30578000 | 0.82 | NPC1 (0.56) | NPC1RAB9ACSNK2A1TRPA1TAS1R3 | |
| SCHEMBL108320 | 0.80 | NFE2L2 (0.47) | NPC1RAB9ACSNK2A1TAS1R3TAS1R1 | |
| SCHEMBL6856523 | 0.80 | NPC1 (0.55) | NPC1RAB9ACSNK2A1TRPA1TAS1R3 | |
| SCHEMBL29495480 | 0.80 | ALDH1A1 (0.57) | NPC1RAB9ACSNK2A1TRPA1TAS1R3 | |
| SCHEMBL760290 | 0.80 | ALDH1A1 (0.57) | NPC1RAB9ACSNK2A1TRPA1TAS1R3 | |
| SCHEMBL168869 | 0.80 | CSNK2A1 (0.69) | NPC1RAB9ACSNK2A1TRPA1MAPT | |
| SCHEMBL8906715 | 0.79 | CES2 (0.70) | CES2MAPTALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111138376-A | 3, 5-disubstituted phenyl-1, 2, 4-oxadiazole derivative and preparation method and application thereof | 中山大学 | 2020-05-12 | — | — | CN | disclosed |
| CN-103992336-B | Oxa-or thia evodiamine anti-tumor derivant and preparation method thereof | 中国人民解放军第二军医大学 | 2017-01-04 | — | — | CN | disclosed |
| CN-103992336-A | Oxa- or thio-evodiamine anti-tumor derivatives and preparation method thereof | UNIV PLA 2ND MILITARY MEDICAL | 2014-08-20 | — | — | CN | disclosed |
| US-20110117649-A1 | Catalytic enantioselective synthesis of flavanones and chromanones | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-05-19 | — | — | US | disclosed |
| US-7851640-B2 | Catalytic enantioselective synthesis of flavanones and chromanones | NORTHWESTERN UNIVERSITY (US) | 2010-12-14 | — | — | US | disclosed |
| US-20090259055-A1 | Catalytic enantioselective synthesis of flavanones and chromanones | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-10-15 | — | — | US | disclosed |
| WO-2009108392-A2 | CATALYTIC ENANTIOSELECTIVE SYNTHESIS OF FLAVANONES AND CHROMANES | NORTHWESTERN UNIVERSITY (US) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090259055-A1 | Catalytic enantioselective synthesis of flavanones and chromanones | RNGTT, CDK20, TBXAS1 | NPC1 4587/4885RAB9A 3477/4885CSNK2A1 3000/4885 |
| US-20110117649-A1 | Catalytic enantioselective synthesis of flavanones and chromanones | RNGTT, CDK20, TBXAS1 | NPC1 4587/4885RAB9A 3477/4885CSNK2A1 3000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.