Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 2/20 | 0.36 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13185576 | 0.88 | TRPV4 (0.35) | LMNAALDH1A1DPP4SHBG | |
| SCHEMBL25027740 | 0.86 | LMNA (0.34) | LMNATYRAGBL2TOP2ARXRA | |
| SCHEMBL16954548 | 0.84 | ALDH1A1 (0.33) | LMNAALDH1A1DPP4SHBG | |
| SCHEMBL21508221 | 0.84 | HTR1D (0.38) | HSP90AA1HSP90AB1LMNAHTR1DTRPA1 | |
| SCHEMBL5265117 | 0.84 | ADRB2 (0.42) | DPP4 | |
| SCHEMBL10289693 | 0.83 | LMNA (0.38) | LMNARNASEH1HTR1DTRPA1PTGS1 | |
| SCHEMBL11951576 | 0.83 | LMNA (0.38) | HSP90AA1HSP90AB1LMNARNASEH1HTR1D | |
| SCHEMBL13091292 | 0.82 | HTR1D (0.42) | LMNAHTR1DTRPA1PTGS1CACNA1C | |
| SCHEMBL765890 | 0.82 | GABRA1 (0.41) | LMNARNASEH1HTR1DTRPA1PTGS1 | |
| SCHEMBL11994355 | 0.82 | GCGR (0.41) | LMNARNASEH1HTR1DTRPA1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| US-20230049402-A1 | NOVEL PHENOL COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO. LTD. (JP) | 2023-02-16 | — | — | US | disclosed |
| WO-2022084741-A1 | CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2022-04-28 | — | — | WO | disclosed |
| US-10695348-B2 | Sulfonyl pyridyl TRP inhibitors | GENENTECH, INC. (US) | 2020-06-30 | — | — | US | disclosed |
| US-20190167681-A1 | SULFONYL PYRIDYL TRP INHIBITORS | GENENTECH, INC. (US) | 2019-06-06 | — | — | US | disclosed |
| WO-2017116928-A1 | FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-07-06 | — | — | WO | disclosed |
| US-20170158697-A1 | Protein Kinase Inhibitors | PHARMASCIENCE INC. (CA) | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10695348-B2 | Sulfonyl pyridyl TRP inhibitors | TRPA1, TRPV1, TRPV5 | HSP90AA1 2341/4885HSP90AB1 1634/4885LMNA 3092/4885 |
| US-20190167681-A1 | SULFONYL PYRIDYL TRP INHIBITORS | TRPA1, TRPV1, TRPV5 | HSP90AA1 2341/4885HSP90AB1 1634/4885LMNA 3092/4885 |
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | HSP90AA1 612/4885HSP90AB1 396/4885LMNA 2015/4885 |
| US-20170158697-A1 | Protein Kinase Inhibitors | TEC, LCK, SRC | HSP90AA1 969/4885HSP90AB1 795/4885LMNA 4651/4885 |
| US-20230049402-A1 | NOVEL PHENOL COMPOUND OR SALT THEREOF | MYB, MLX, EP300 | HSP90AA1 3654/4885HSP90AB1 4167/4885LMNA 2792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.