Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019919 | 0.89 | HIF1A (0.47) | L3MBTL1HSD17B10PKMCHRNB2CHRNA4 | |
| SCHEMBL19061883 | 0.88 | MEN1 (0.48) | NPC1RAB9AHSD17B10PKMCHRNB2 | |
| SCHEMBL19019922 | 0.88 | MAPK1 (0.50) | RAB9AHSD17B10PKMCHRNB2CHRNA4 | |
| SCHEMBL14286352 | 0.86 | OPRK1 (0.48) | HSD17B10PKMCHRNB2CHRNA4MEN1 | |
| SCHEMBL19019870 | 0.86 | CHRNB2 (0.43) | NPC1RAB9AHSD17B10PKMCHRNB2 | |
| SCHEMBL19019834 | 0.86 | PLA2G7 (0.47) | NPC1RAB9AHSD17B10PKMCHRNB2 | |
| SCHEMBL19019921 | 0.85 | PKM (0.48) | NPC1RAB9AHSD17B10PKMCHRNB2 | |
| SCHEMBL19061892 | 0.82 | MMP1 (0.43) | HSD17B10PKMCHRNB2CHRNA4MAPK1 | |
| SCHEMBL19019907 | 0.82 | LMNA (0.41) | CHRNB2CHRNA4MEN1KMT2AMAPK1 | |
| SCHEMBL19061885 | 0.82 | MEN1 (0.52) | L3MBTL1HSD17B10PKMCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |