Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19061884 | 0.89 | KMT2A (0.49) | KDM4EALDH1A1LMNAPKMPOLB | |
| SCHEMBL19061887 | 0.86 | L3MBTL1 (0.51) | LMNAMAPTPKMP2RX7MAPK1 | |
| SCHEMBL19019834 | 0.86 | PLA2G7 (0.47) | ALDH1A1MAPTPKMPOLBALOX12 | |
| SCHEMBL19061952 | 0.83 | CYP1A2 (0.51) | KDM4EMAPTPKMP2RX7SIGMAR1 | |
| SCHEMBL19062035 | 0.82 | HSD17B10 (0.40) | KDM4EALDH1A1MAPTPKMPOLB | |
| SCHEMBL19019922 | 0.81 | MAPK1 (0.50) | KDM4EALDH1A1PKMPOLBMAPK1 | |
| SCHEMBL19061452 | 0.80 | PKM (0.48) | PKMPOLBMAPK1KMT2AHSD17B10 | |
| SCHEMBL19061593 | 0.80 | ALDH1A1 (0.46) | KDM4EALDH1A1PKMPOLBHPGD | |
| SCHEMBL19062037 | 0.79 | METAP2 (0.43) | KDM4EALDH1A1MAPTPKMMAPK1 | |
| SCHEMBL19061954 | 0.79 | HSD17B10 (0.42) | KDM4EALDH1A1MAPTPKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |