Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19062037 | 0.88 | METAP2 (0.43) | ALDH1A1KDM4EHSD17B10PKMMAPK1 | |
| SCHEMBL19061464 | 0.84 | GSK3A (0.41) | ALDH1A1HSD17B10PKMALOX15MAPK1 | |
| SCHEMBL19061459 | 0.83 | RAB9A (0.46) | ALDH1A1HPGDKDM4ELMNAHSD17B10 | |
| SCHEMBL19019870 | 0.83 | CHRNB2 (0.43) | ALDH1A1TSHRHPGDKDM4ELMNA | |
| SCHEMBL19062034 | 0.82 | GFER (0.44) | ALDH1A1KDM4EHSD17B10ALOX15MAPK1 | |
| SCHEMBL19061954 | 0.82 | HSD17B10 (0.42) | ALDH1A1KDM4EHSD17B10PKMMAPK1 | |
| SCHEMBL19061887 | 0.81 | L3MBTL1 (0.51) | TSHRLMNAHSD17B10PKMMAPK1 | |
| SCHEMBL19019834 | 0.81 | PLA2G7 (0.47) | ALDH1A1HSD17B10PKMALOX12MAPK1 | |
| SCHEMBL19019922 | 0.80 | MAPK1 (0.50) | ALDH1A1KDM4EHSD17B10PKMMAPK1 | |
| SCHEMBL19061952 | 0.80 | CYP1A2 (0.51) | KDM4EHSD17B10PKMMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |