Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019922 | 0.86 | MAPK1 (0.50) | CHRNB2CHRNA4MAPK1HSD17B10PKM | |
| SCHEMBL19061954 | 0.83 | HSD17B10 (0.42) | CHRNB2CHRNA4MAPK1HSD17B10PKM | |
| SCHEMBL19061459 | 0.83 | RAB9A (0.46) | CHRNB2CHRNA4MAPK1HSD17B10PKM | |
| SCHEMBL19061883 | 0.82 | MEN1 (0.48) | CHRNB2CHRNA4MAPK1HSD17B10PKM | |
| SCHEMBL19019870 | 0.82 | CHRNB2 (0.43) | CHRNB2CHRNA4MAPK1HSD17B10PKM | |
| SCHEMBL14286352 | 0.82 | OPRK1 (0.48) | CHRNB2CHRNA4MAPK1HSD17B10PKM | |
| SCHEMBL19019834 | 0.82 | PLA2G7 (0.47) | CHRNB2CHRNA4MAPK1HSD17B10PKM | |
| SCHEMBL19062011 | 0.81 | ALDH1A1 (0.46) | MAPK1HSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL19061885 | 0.80 | MEN1 (0.52) | CHRNB2CHRNA4MAPK1HSD17B10PKM | |
| SCHEMBL19061887 | 0.80 | L3MBTL1 (0.51) | CHRNB2CHRNA4MAPK1HSD17B10PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184514-A1 | AUTOPHAGY INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2017-06-28 | — | — | EP | disclosed |