Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 3/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19194978 | 0.85 | ACHE (0.44) | ITGB1ITGA5 | |
| SCHEMBL16914900 | 0.83 | MAPK1 (0.51) | ALDH1A1VCAM1TTRCASP6MAPT | |
| SCHEMBL4605109 | 0.82 | VCAM1 (0.62) | ALDH1A1HIF1AVCAM1ITGB1ITGA5 | |
| SCHEMBL17687690 | 0.82 | VCAM1 (0.68) | ALDH1A1VCAM1MAPTLMNAMEN1 | |
| SCHEMBL1625971 | 0.82 | LMNA (0.66) | ALDH1A1CASP6MAPTLMNAMEN1 | |
| SCHEMBL20405101 | 0.81 | TTR (0.45) | ALDH1A1HIF1AVCAM1TTRCASP6 | |
| SCHEMBL8626465 | 0.81 | TTR (0.62) | ALDH1A1HIF1AVCAM1ITGB1ITGA5 | |
| SCHEMBL24994 | 0.81 | CASP6 (0.70) | ALDH1A1HIF1AVCAM1AKR1C2AKR1C1 | |
| SCHEMBL9157 | 0.79 | ITGB1 (0.57) | ALDH1A1HIF1AVCAM1ITGB1ITGA5 | |
| SCHEMBL3476754 | 0.79 | PARP1 (0.65) | ALDH1A1HIF1AVCAM1ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240409533-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-12-12 | — | — | US | disclosed |
| US-12071433-B2 | HMOX1 inducers | Astellas Engineered Small Molecules US, Incorporated (US) | 2024-08-27 | — | — | US | disclosed |
| US-20240051952-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-02-15 | — | — | US | disclosed |
| US-20220177460-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2022-06-09 | — | — | US | disclosed |
| EP-3952990-A1 | HMOX1 INDUCERS | Mitobridge, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-113874074-A | HMOX1 inducers | 米托布里奇公司 | 2021-12-31 | — | — | CN | disclosed |
| WO-2020210339-A1 | HMOX1 INDUCERS | MITOBRIDGE, INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| US-10766888-B1 | HMOX1 inducers | MITOBRIDGE INC. (US) | 2020-09-08 | — | — | US | disclosed |
| EP-3207023-B1 | PROCESS FOR THE PREPARATION OF 1-(3,5-DICHLOROPHENYL)-2,2,2-TRIFLUOROETHANONE AND DERIVATIVES THEREOF | SYNGENTA PARTICIPATIONS AG (CH) | 2019-09-18 | — | — | EP | disclosed |
| EP-3207023-B1 | PROCESS FOR THE PREPARATION OF 1-(3,5-DICHLOROPHENYL)-2,2,2-TRIFLUOROETHANONE AND DERIVATIVES THEREOF | SYNGENTA PARTICIPATIONS AG (CH) | 2019-09-18 | — | — | EP | disclosed |
| US-10040745-B2 | Process for the preparation of 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone and derivatives thereof | SYNGENTA PARTICIPATIONS AG (CH) | 2018-08-07 | — | — | US | disclosed |
| EP-3207023-A2 | PROCESS FOR THE PREPARATION OF HALO-SUBSTITUTED BENZENES | Syngenta Participations AG (CH) | 2017-08-23 | — | — | EP | disclosed |
| US-20170217865-A1 | PROCESS FOR THE PREPARATION OF 1-(3,5-DICHLOROPHENYL)-2,2,2-TRIFLUOROETHANONE AND DERIVATIVES THEREOF | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-03 | — | — | US | disclosed |
| WO-2016058881-A2 | PROCESS FOR THE PREPARATION OF HALO-SUBSTITUTED BENZENES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-04-21 | — | — | WO | disclosed |
| WO-2016058881-A2 | PROCESS FOR THE PREPARATION OF HALO-SUBSTITUTED BENZENES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-04-21 | — | — | WO | disclosed |
| US-20140142069-A1 | SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-05-22 | — | — | US | disclosed |
| EP-2493845-A1 | SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2012-09-05 | — | — | EP | disclosed |
| US-20110130445-A1 | SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-06-02 | — | — | US | disclosed |
| WO-2011051165-A1 | SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10766888-B1 | HMOX1 inducers | HMOX1, HMOX2, HMBS | ALDH1A1 332/4885HIF1A 271/4885VCAM1 951/4885 |
| US-20170217865-A1 | PROCESS FOR THE PREPARATION OF 1-(3,5-DICHLOROPHENYL)-2,2,2-TRIFLUOROETHANONE AND DERIVATIVES THEREOF | CBR1, CBR3, CYP2F1 | ALDH1A1 363/4885HIF1A 64/4885VCAM1 4151/4885 |
| US-20140142069-A1 | SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF | FABP3, PC, PAH | ALDH1A1 431/4885HIF1A 932/4885VCAM1 455/4885 |
| US-20110130445-A1 | SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF | FABP3, PC, PAH | ALDH1A1 431/4885HIF1A 932/4885VCAM1 455/4885 |
| US-20240409533-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | ALDH1A1 332/4885HIF1A 271/4885VCAM1 951/4885 |
| US-12071433-B2 | HMOX1 inducers | HMOX1, HMOX2, HMBS | ALDH1A1 223/4885HIF1A 244/4885VCAM1 926/4885 |
| US-20240051952-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, QSOX1 | ALDH1A1 266/4885HIF1A 150/4885VCAM1 265/4885 |
| US-10040745-B2 | Process for the preparation of 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone and derivatives thereof | CBR1, CBR3, CYP2F1 | ALDH1A1 363/4885HIF1A 64/4885VCAM1 4151/4885 |
| US-20220177460-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | ALDH1A1 223/4885HIF1A 244/4885VCAM1 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.