Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 4/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LAP3 | P28838 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633094 | 1.00 | SLC1A3 (0.44) | SLC1A3SLC1A2MMECPA1CYP2D6 | |
| SCHEMBL1705392 | 1.00 | SLC1A3 (0.44) | SLC1A3SLC1A2MMECPA1CYP2D6 | |
| Methane SCHEMBL8795616 | 0.98 | SLC1A3 (0.43) | SLC1A3SLC1A2MMECPA1CYP2D6 | |
| SCHEMBL4839844 | 0.86 | MEN1 (0.47) | CYP2D6MEN1GAAKMT2AHDAC3 | |
| SCHEMBL8348140 | 0.86 | CYP2D6 (0.43) | SLC1A3SLC1A2MMECYP2D6MEN1 | |
| SCHEMBL20054394 | 0.85 | KISS1R (0.43) | CYP2D6CTSLCTSBCTSSCTSK | |
| SCHEMBL15116513 | 0.85 | KISS1R (0.43) | CYP2D6CTSLCTSBCTSSCTSK | |
| SCHEMBL27506606 | 0.84 | CYP2D6 (0.39) | SLC1A3SLC1A2MMECYP2D6MEN1 | |
| SCHEMBL1199791 | 0.84 | CYP2D6 (0.39) | SLC1A3SLC1A2MMECYP2D6MEN1 | |
| SCHEMBL15113889 | 0.84 | CYP2D6 (0.41) | SLC1A3SLC1A2CYP2D6CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222858-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | PIERRE FABRE MEDICAMENT (FR) | 2018-08-09 | — | — | US | disclosed |
| US-10022418-B2 | Compositions and methods for treating beta-amyloid related diseases | AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20180037606-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | APICORE US LLC (US) | 2018-02-08 | — | — | US | disclosed |
| US-9822145-B2 | Methods of making carfilzomib and intermediates thereof | APICORE US LLC (US) | 2017-11-21 | — | — | US | disclosed |
| US-20170166543-A1 | COMPOSITIONS AND METHODS FOR SYNTHESIZING (2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYL-AMIDO-3-METHYLBUTANE ETHYL ESTER | AMERICAN LIFE SCIENCE PHARMACEUTICALS INC (US) | 2017-06-15 | — | — | US | disclosed |
| US-9586958-B2 | Prodrug derivatives of substituted triazolopyridines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-03-07 | — | — | US | disclosed |
| US-20170057911-A1 | SYNTHESIS OF ARYL CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | PROCTER & GAMBLE (US) | 2017-03-02 | — | — | US | disclosed |
| US-20160340388-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | APICORE US LLC (US) | 2016-11-24 | — | — | US | disclosed |
| US-20160207915-A1 | PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-07-21 | — | — | US | disclosed |
| US-20160115198-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | MYLAN API US LLC | 2016-04-28 | — | — | US | disclosed |
| WO-1994021625-A1 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |
| US-5304604-A | Treating diseases involving tissue degradation, promoting wound healing | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-04-19 | — | — | US | disclosed |
| US-5304549-A | Control or prevention of degenerative joint diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-04-19 | — | — | US | disclosed |
| EP-0445206-B1 | HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS | BRITISH BIO TECHNOLOGY (GB) | 1994-03-16 | — | — | EP | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| WO-1993010144-A1 | NEW ENDOTHELIN ANTAGONISTS AND THEIR PREPARATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-27 | — | — | WO | disclosed |
| EP-0497192-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-08-05 | — | — | EP | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |
| US-4996358-A | Control, prevention rheumatic diseases | HOFFMANN-LA ROCHE INC. (US) | 1991-02-26 | — | — | US | disclosed |
| WO-1990005716-A1 | HYDROXAMIC ACID BASED COLLAGENASE INHIBITORS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207915-A1 | PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES | TK1, PNKP, MPST | SLC1A3 2510/4885SLC1A2 3076/4885MME 1962/4885 |
| US-20160340388-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | PAICS, RCE1, CPSF1 | SLC1A3 4832/4885SLC1A2 4875/4885MME 682/4885 |
| US-10022418-B2 | Compositions and methods for treating beta-amyloid related diseases | APP, BACE1, PTMS | SLC1A3 2285/4885SLC1A2 3063/4885MME 212/4885 |
| US-20180222858-A1 | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS | NR1H4, HCAR3, VDR | SLC1A3 1946/4885SLC1A2 3587/4885MME 3779/4885 |
| US-20180037606-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | PAICS, RCE1, CPSF1 | SLC1A3 4832/4885SLC1A2 4875/4885MME 682/4885 |
| US-20170166543-A1 | COMPOSITIONS AND METHODS FOR SYNTHESIZING (2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYL-AMIDO-3-METHYLBUTANE ETHYL ESTER | PTMS, LTA, LPXN | SLC1A3 275/4885SLC1A2 735/4885MME 1199/4885 |
| US-20160115198-A1 | METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF | PAICS, RCE1, CPSF1 | SLC1A3 4832/4885SLC1A2 4875/4885MME 682/4885 |
| US-20170057911-A1 | SYNTHESIS OF ARYL CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | CUTA, ACMSD, SRM | SLC1A3 436/4885SLC1A2 466/4885MME 2959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.