Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | CDC25B | P30305 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GGT1 | P19440 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652894 | 0.83 | TSHR (0.48) | ALDH1A1ALOX15KDM4EHSD17B10KMT2A | |
| SCHEMBL3929070 | 0.83 | PARP1 (0.41) | HTTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3503701 | 0.80 | LMNA (0.43) | HTTALDH1A1ALOX15KDM4EHPGD | |
| SCHEMBL7387055 | 0.80 | HMGCR (0.41) | ALDH1A1KDM4EHPGDKMT2AUSP2 | |
| SCHEMBL3505181 | 0.78 | ALDH1A1 (0.45) | HTTALDH1A1ALOX15KDM4EHPGD | |
| SCHEMBL23039128 | 0.78 | L3MBTL1 (0.44) | HTTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL5132767 | 0.78 | TSHR (0.58) | HTTALDH1A1ALOX15KDM4EHPGD | |
| SCHEMBL20797165 | 0.76 | LMNA (0.46) | HTTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL6718464 | 0.76 | CA1 (0.41) | HTTALDH1A1ALOX15KDM4EHPGD | |
| SCHEMBL826011 | 0.75 | ALDH1A1 (0.38) | ALDH1A1ALOX15KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230122243-A1 | Heteroaromatic inhibitors of astacin proteinases | VIVORYON THERAPEUTICS N.V. (DE) | 2023-04-20 | — | — | US | claimed |
| EP-2090571-B1 | Pyrimidine derivates, medicaments comprising them, their use and process of their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 2012-05-16 | — | — | EP | claimed |
| EP-2332924-A1 | Pyrimidine derivates, medicaments comprising them, their use and process of their preparation | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-06-15 | — | — | EP | claimed |
| JP-4460292-B2 | — | — | 2010-05-12 | — | — | JP | claimed |
| US-7709480-B2 | Pyrimidine derivatives | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-05-04 | — | — | US | claimed |
| EP-1438053-B1 | PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-09-10 | — | — | EP | claimed |
| US-7173028-B2 | Pyrimidine derivatives | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-02-06 | — | — | US | claimed |
| US-20060100211-A1 | Pyrimidine derivatives | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-05-11 | — | — | US | claimed |
| JP-2005509624-A | — | — | 2005-04-14 | — | — | JP | claimed |
| EP-1438053-A1 | PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-07-21 | — | — | EP | claimed |
| US-20030171359-A1 | Suitable for treatment of illnesses characterised by excessive or abnormal cell proliferation; viral, bacterial, fungal and/or parasitic infections, skin diseases, bone diseases, cardiovascular diseases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-09-11 | — | — | US | claimed |
| WO-2003032997-A1 | PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-04-24 | — | — | WO | claimed |
| WO-2000024725-A1 | PENTACYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HEPATITIS C VIRUS NS3 HELICASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-05-04 | — | — | WO | claimed |
| US-20230348438-A1 | PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2023-11-02 | — | — | US | disclosed |
| US-20200317644-A1 | PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2020-10-08 | — | — | US | disclosed |
| CN-110317328-A | The preparation method of polyarylate of the one kind based on 2- (4- carboxyl -3- methoxyphenyl) -5- pyridone and imidazoles | 浙江甬仑聚嘉新材料有限公司 | 2019-10-11 | — | — | CN | disclosed |
| US-4098758-A | ORGANIC ACIDS, FOR USE IN POLYMER SYSTEMS | KENRICH PETROCHEMICALS, INC. (US) | 1978-07-04 | — | — | US | disclosed |
| US-4096110-A | Filled polyesters containing organic titanate esters | KENRICH PETROCHEMICALS, INC. (US) | 1978-06-20 | — | — | US | disclosed |
| US-4094853-A | Alkoxy titanate salts useful as coupling agents | KENRICH PETROCHEMICALS, INC. (US) | 1978-06-13 | — | — | US | disclosed |
| US-4087402-A | USED FOR TREATMENT OF INORGANIC FILLERS | KENRICH PETROCHEMICALS, INC. (US) | 1978-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230122243-A1 | Heteroaromatic inhibitors of astacin proteinases | BMP1, DPEP1, MEP1A | HTT 2952/4885ALDH1A1 2800/4885ALOX15 979/4885 |
| US-20230348438-A1 | PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | CYP2C19, CYP3A7, CYP3A5 | HTT 2225/4885ALDH1A1 1200/4885ALOX15 3298/4885 |
| US-20060100211-A1 | Pyrimidine derivatives | TYMP, TYMS, DPYD | HTT 3317/4885ALDH1A1 252/4885ALOX15 1772/4885 |
| US-20200317644-A1 | PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | CYP2C19, CYP3A7, CYP3A5 | HTT 2225/4885ALDH1A1 1200/4885ALOX15 3298/4885 |
| US-20030171359-A1 | Suitable for treatment of illnesses characterised by excessive or abnormal cell proliferation; viral, bacterial, fungal and/or parasitic infections, skin diseases, bone diseases, cardiovascular diseases | COL1A1, MKI67, INSR | HTT 4543/4885ALDH1A1 605/4885ALOX15 1263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.