Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.59 |
| ▸ | FEN1 | P39748 | 1/20 | 0.59 |
| ▸ | PLOD2 | O00469 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.46 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.44 |
| ▸ | WNT3A | P56704 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8735550 | 0.82 | ERCC5 (0.74) | ERCC5FEN1MEN1NPC1RAB9A | |
| SCHEMBL1924959 | 0.80 | PTPN1 (0.61) | ERCC5FEN1PLOD2MEN1NPC1 | |
| SCHEMBL4588485 | 0.79 | PLOD2 (0.49) | PLOD2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL16014065 | 0.79 | MEN1 (0.54) | PLOD2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3474396 | 0.79 | LMNA (0.56) | PLOD2PLOD3PLOD1CTNNB1WNT3A | |
| SCHEMBL31475594 | 0.79 | LMNA (0.56) | PLOD2PLOD3PLOD1CTNNB1WNT3A | |
| SCHEMBL1923885 | 0.79 | ERCC5 (0.59) | ERCC5FEN1PLOD2MEN1NPC1 | |
| SCHEMBL9072150 | 0.78 | NPC1 (0.62) | PLOD2NPC1RAB9AKMT2AL3MBTL1 | |
| SCHEMBL3660192 | 0.77 | ERCC5 (0.72) | ERCC5FEN1MEN1NPC1RAB9A | |
| SCHEMBL8383887 | 0.77 | ERCC5 (0.67) | ERCC5FEN1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759497-B2 | Synthesis of diaryl pyrazoles | PFIZER INC. (US) | 2010-07-20 | — | — | US | claimed |
| US-20070004924-A1 | such as (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-1-yl]benzenesulfonamide), celecoxib, via reacting 1,3-diketone and 4-sulfamidophenyl hydrazine halide salt in solvent system containing isopropanol | PHARMACIA CORPORATION | 2007-01-04 | — | — | US | claimed |
| EP-1507766-A4 | SYNTHESIS OF DIARYL PYRAZOLES | PHARMACIA CORP (US) | 2006-06-14 | — | — | EP | claimed |
| EP-1507766-A1 | SYNTHESIS OF DIARYL PYRAZOLES | Pharmacia Corporation (US) | 2005-02-23 | — | — | EP | claimed |
| US-20040024225-A1 | Synthesis of diaryl pyrazoles | PHARMACIA CORPORATION | 2004-02-05 | — | — | US | claimed |
| WO-2003099794-A1 | SYNTHESIS OF DIARYL PYRAZOLES | PHARMACIA CORPORATION (US) | 2003-12-04 | — | — | WO | claimed |
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |
| EP-1670801-B1 | PYRAZOLO AND IMIDAZO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-06-08 | — | — | EP | disclosed |
| US-7759497-B2 | Synthesis of diaryl pyrazoles | PFIZER INC. (US) | 2010-07-20 | — | — | US | disclosed |
| US-7514443-B2 | Substituted pyrazolo[1,5-a]pyrimidines as inhibitors of metabotropic glutamate receptors | HOFFMANN-LA ROCHE INC. (US) | 2009-04-07 | — | — | US | disclosed |
| EP-1377289-A4 | HETEROCYCLIC COMPOUNDS FOR THERAPEUTIC USE | JB CHEMICALS & PHARMACEUTICALS (IN) | 2008-09-10 | — | — | EP | disclosed |
| US-20080051421-A1 | Pyrazolo-pyridine | WICHMANN JUERGEN | 2008-02-28 | — | — | US | disclosed |
| EP-1377289-A2 | HETEROCYCLIC COMPOUNDS FOR THERAPEUTIC USE | J.B. Chemicals & Pharmaceuticals Ltd. (IN) | 2004-01-07 | — | — | EP | disclosed |
| EP-0821297-B1 | Method for controlling traveling using a luminescent compound | MITSUI CHEMICALS INC (JP) | 2002-10-09 | — | — | EP | disclosed |
| WO-2002074235-A2 | HETEROCYCLIC COMPOUNDS FOR THERAPEUTIC USE | J.B. CHEMICALS & PHARMACEUTICALS LTD (IN) | 2002-09-26 | — | — | WO | disclosed |
| US-6403629-B2 | 1-(P-(METHYLSULFONAMIDO)PHENYL)-3-TRIFLUOROMETHYL-5-PHENYLPYRA ZOLONE AND DERIVATIVES; ANTIINFLAMMATORY AGENTS | J.B. CHEMICAL AND PHARMACEUTICALS LIMITED (IN) | 2002-06-11 | — | — | US | disclosed |
| US-20010047023-A1 | New Heterocyclic compounds for therapeutic use | J.B. CHEMICALS & PHARMACEUTICALS LIMITED | 2001-11-29 | — | — | US | disclosed |
| US-6203725-B1 | FOR CONTROLLING TRAVELING OF A TRAVELING ARTICLES INCLUDING AUTOMATIC GUIDED VEHICLES SUCH AS INDUSTRIAL ROBOT | MITSUI CHEMICALS, INC. (JP) | 2001-03-20 | — | — | US | disclosed |
| EP-0821297-A1 | Luminescent compound for controlling traveling and method for controlling traveling using the same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1998-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004924-A1 | such as (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazole-1-yl]benzenesulfonamide), celecoxib, via reacting 1,3-diketone and 4-sulfamidophenyl hydrazine halide salt in solvent system containing isopropanol | KHK, GCK, SYMPK | ERCC5 4822/4885FEN1 4843/4885PLOD2 3796/4885 |
| US-20010047023-A1 | New Heterocyclic compounds for therapeutic use | AADAC, NAT1, FPR1 | ERCC5 4247/4885FEN1 4498/4885PLOD2 2358/4885 |
| US-20040024225-A1 | Synthesis of diaryl pyrazoles | HDHD5, PDCD2L, HELZ | ERCC5 3938/4885FEN1 4497/4885PLOD2 4000/4885 |
| US-20080051421-A1 | Pyrazolo-pyridine | CHRM2, CHRM1, QDPR | ERCC5 4469/4885FEN1 4584/4885PLOD2 3738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.