Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR1 | P30872 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4244351 | 1.00 | SSTR1 (0.63) | SSTR1HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL6430387 | 1.00 | SSTR1 (0.63) | SSTR1HTR2AADRB1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL6723717 | 0.99 | SSTR1 (0.62) | SSTR1HTR2AADRB1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL27472186 | 0.99 | SSTR1 (0.62) | SSTR1HTR2AADRB1HTR1AADRA2A | |
| Hexane SCHEMBL27589497 | 0.93 | SSTR1 (0.56) | SSTR1HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL3012885 | 0.90 | SSTR1 (0.53) | SSTR1HTR2AADRB1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL27542605 | 0.90 | SSTR1 (0.53) | SSTR1HTR2AADRB1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL1723213 | 0.90 | SSTR1 (0.53) | SSTR1HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL13244865 | 0.90 | SSTR1 (0.53) | SSTR1HTR2AADRB1HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL3019998 | 0.89 | SSTR1 (0.52) | SSTR1HTR2AADRB1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146627-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | LASSAUNIERE PIERRE-ETIENNE CHA | 2008-06-19 | — | — | US | claimed |
| US-20070032653-A1 | N-{1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methylhexyl}-N-cyclohexylamine; agonists or antagonists of somatostatin receptors; acromegaly, restenosis, Crohn's disease, systemic sclerosis, external and internal pancreatic pseudocysts and ascites, nesidoblastosis, hyperinsulinism, gastrinoma, etc. | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. (FR) | 2007-02-08 | — | — | US | claimed |
| US-20050038087-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | IPSEN PHARMA S.A.S. (FR) | 2005-02-17 | — | — | US | claimed |
| US-20040132788-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-07-08 | — | — | US | claimed |
| EP-1305294-A2 | IMIDAZOLYL DERIVATIVES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2003-05-02 | — | — | EP | claimed |
| CN-1391474-A | 5-membered heterocyclic derivatives, their preparation and their use as medicaments | SOD CONSEILS RECH APPLIC (FR) | 2003-01-15 | — | — | CN | claimed |
| EP-1228760-A2 | 5-membered heterocycle derivatives, production thereof and use thereof as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-08-07 | — | — | EP | claimed |
| WO-2002010140-A2 | IMIDAZOLYL DERIVATIVES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-02-07 | — | — | WO | claimed |
| US-20200360483-A1 | METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE | IPSEN PHARMA S.A.S. (FR) | 2020-11-19 | — | — | US | disclosed |
| US-20200347110-A1 | Composition and Methods for Stimulating Gastrointestinal Motility | IPSEN PHARMA S.A.S. (FR) | 2020-11-05 | — | — | US | disclosed |
| US-20190248861-A1 | Composition and Methods for Stimulating Gastrointestinal Motility | IPSEN PHARMA S.A.S. (FR) | 2019-08-15 | — | — | US | disclosed |
| EP-1937262-B1 | COMPOSITION FOR USE IN TREATING GASTROINTESTINAL DYSMOTILITY | IPSEN PHARMA (FR) | 2019-05-08 | — | — | EP | disclosed |
| US-20170362275-A1 | Growth Hormone Releasing Peptides | IPSEN PHARMA S.A.S. (FR) | 2017-12-21 | — | — | US | disclosed |
| US-20170304403-A1 | METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE | IPSEN PHARMA S.A.S. (FR) | 2017-10-26 | — | — | US | disclosed |
| WO-2002010140-A2 | IMIDAZOLYL DERIVATIVES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-02-07 | — | — | WO | disclosed |
| CN-1319094-A | Imidazolyl derivatives | SOD CONSEILS RECH APPLIC (FR) | 2001-10-24 | — | — | CN | disclosed |
| EP-1086086-A1 | IMIDAZOLYL DERIVATIVES AND THEIR USE AS SOMATOSTATIN RECEPTOR LIGANDS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S. (FR) | 2001-03-28 | — | — | EP | disclosed |
| EP-1086101-A1 | BETA-CARBOLINE COMPOUNDS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S. (FR) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064420-A1 | β-CARBOLINE COMPOUNDS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S (FR) | 1999-12-16 | — | — | WO | disclosed |
| WO-1999064401-A2 | IMIDAZOLYL DERIVATIVES AND THEIR USE AS SOMATOSTATIN RECEPTOR LIGANDS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES SAS (FR) | 1999-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170304403-A1 | METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE | PROKR1, CCL2, PROKR2 | SSTR1 274/4885HTR2A 872/4885ADRB1 1076/4885 |
| US-20200360483-A1 | METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE | PROKR1, CCL2, PROKR2 | SSTR1 274/4885HTR2A 872/4885ADRB1 1076/4885 |
| US-20050038087-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | OXER1, OPRL1, OPRK1 | SSTR1 1981/4885HTR2A 835/4885ADRB1 151/4885 |
| US-20040132788-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | OPRK1, HCN1, P2RX7 | SSTR1 1927/4885HTR2A 665/4885ADRB1 93/4885 |
| US-20080146627-A1 | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments | OXER1, OPRL1, P2RX7 | SSTR1 2451/4885HTR2A 1364/4885ADRB1 269/4885 |
| US-20170362275-A1 | Growth Hormone Releasing Peptides | GHRHR, THRB, PRLHR | SSTR1 40/4885HTR2A 409/4885ADRB1 237/4885 |
| US-20190248861-A1 | Composition and Methods for Stimulating Gastrointestinal Motility | GIPR, VIP, GRPR | SSTR1 36/4885HTR2A 690/4885ADRB1 1320/4885 |
| US-20070032653-A1 | N-{1-(4-(3-bromophenyl)-1H-imidazol-2-yl)-5-methylhexyl}-N-cyclohexylamine; agonists or antagonists of somatostatin receptors; acromegaly, restenosis, Crohn's disease, systemic sclerosis, external and internal pancreatic pseudocysts and ascites, nesidoblastosis, hyperinsulinism, gastrinoma, etc. | GHSR, IGF1R, GIPR | SSTR1 4/4885HTR2A 296/4885ADRB1 31/4885 |
| US-20200347110-A1 | Composition and Methods for Stimulating Gastrointestinal Motility | GIPR, VIP, GRPR | SSTR1 36/4885HTR2A 690/4885ADRB1 1320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.