SCHEMBL19633940

SCHEMBL19633940

C=CNCc1ccc(-c2ccc(-c3ccc(C)c(F)c3F)cc2)c(F)c1F

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHKA P35790 1/20 0.35
P2RX7 Q99572 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL802797 0.80 GABRA1 (0.35) CHKA
SCHEMBL12140868 0.78 CHKA (0.33) CHKA
SCHEMBL21019482 0.76 ALDH1A1 (0.40)
SCHEMBL803253 0.75 PTGS2 (0.38) CHKA
SCHEMBL13394256 0.73 CTSL (0.43) CHKA
SCHEMBL15681344 0.73 ALDH1A1 (0.41)
SCHEMBL18134247 0.72 ALDH1A1 (0.41) CHKA
SCHEMBL11938840 0.72 CTSL (0.42) CHKA
SCHEMBL17108398 0.71 TYR (0.38) CHKA
SCHEMBL16852477 0.71 GABRA1 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230053362-A1 DICHROIC DYE COMPOSITION MERCK PATENT GMBH (DE) 2023-02-23 US disclosed
US-20220025265-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2022-01-27 US disclosed
US-11225606-B2 Polymerizable compounds and the use thereof in liquid-crystal displays MERCK PATENT GMBH (DE) 2022-01-18 US disclosed
US-20210348056-A1 Polymerisable Compounds and the Use thereof in Liquid-Crystal Displays MERCK PATENT GMBH (DE) 2021-11-11 US disclosed
US-11168257-B2 Liquid crystalline medium MERCK PATENT GMBH (DE) 2021-11-09 US disclosed
US-20210292652-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2021-09-23 US disclosed
US-20210277310-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2021-09-09 US disclosed
US-11053442-B2 Liquid crystal mixture and liquid crystal display MERCK PATENT GMBH (DE) 2021-07-06 US disclosed
US-11015121-B2 Liquid crystal displays and liquid crystalline media with homeotropic alignment MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2021-05-25 US disclosed
US-20210139781-A1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2021-05-13 US disclosed
US-20190284474-A1 SWITCHING LAYER FOR USE IN AN OPTICAL SWITCHING ELEMENT MERCK PATENT GMBH (DE) 2019-09-19 US disclosed
US-20190264105-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2019-08-29 US disclosed
US-20190256777-A1 POLYMERIZABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2019-08-22 US disclosed
US-20190256771-A1 LIQUID CRYSTAL DISPLAYS AND LIQUID CRYSTALLINE MEDIA WITH HOMEOTROPIC ALIGNMENT MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2019-08-22 US disclosed
US-20190241811-A1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-08-08 US disclosed
US-20190218457-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-07-18 US disclosed
US-20190185748-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2019-06-20 US disclosed
US-10301544-B2 Liquid-crystal medium MERCK PATENT GMBH (DE) 2019-05-28 US disclosed
US-20190153320-A1 LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2019-05-23 US disclosed
US-20170335195-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2017-11-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11225606-B2 Polymerizable compounds and the use thereof in liquid-crystal displays VCL, PLEC, EML4 CHKA 3032/4885P2RX7 3763/4885
US-20190256777-A1 POLYMERIZABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS VCL, PLEC, EML4 CHKA 3032/4885P2RX7 3763/4885
US-20210139781-A1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS VCL, ILK, LCP1 CHKA 3088/4885P2RX7 4129/4885
US-20210292652-A1 LIQUID CRYSTAL MIXTURE AND LIQUID CRYSTAL DISPLAY CXCR1, PYM1, F11 CHKA 4829/4885P2RX7 2162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.