Sugi Predict

Sugi Predict / Compounds / SCHEMBL1965205

SCHEMBL1965205

SCHEMBL1965205

CCOC(=O)c1ccc(NC)c([N+](=O)[O-])c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.76
▸ ALDH1A1 P00352 5/20 0.74
▸ MAPT P10636 4/20 0.74
▸ RAB9A P51151 2/20 0.74
▸ NPC1 O15118 1/20 0.74
▸ PKM P14618 1/20 0.74
▸ CRHBP P24387 1/20 0.74
▸ CRHR2 Q13324 1/20 0.74
▸ LMNA P02545 1/20 0.73
▸ KDM4E B2RXH2 1/20 0.73
▸ POLB P06746 1/20 0.73
▸ PTGER4 P35408 1/20 0.70
▸ HCAR3 P49019 4/20 0.65
▸ CDC25B P30305 1/20 0.55
▸ TDP1 Q9NUW8 2/20 0.54
▸ GAA P10253 1/20 0.52
▸ SMN1; SMN2 Q16637 1/20 0.52
▸ HTT P42858 1/20 0.51
▸ MAPK1 P28482 1/20 0.51
▸ RECQL P46063 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2248072 0.89 KMT2A (0.64) KMT2AALDH1A1MAPTRAB9ANPC1
SCHEMBL22382354 0.88 MAPT (0.81) KMT2AALDH1A1MAPTRAB9ANPC1
SCHEMBL6170744 0.86 KMT2A (1.00) KMT2AALDH1A1MAPTRAB9ANPC1
SCHEMBL27011566 0.86 HCAR3 (0.61) KMT2AALDH1A1MAPTRAB9ANPC1
SCHEMBL1726941 0.85 HCAR3 (0.72) KMT2AALDH1A1MAPTRAB9ANPC1
SCHEMBL4332105 0.85 KMT2A (0.71) KMT2AALDH1A1MAPTRAB9ANPC1
Hydrochloric Acid SCHEMBL27006241 0.85 HCAR3 (0.59) KMT2AALDH1A1MAPTRAB9ANPC1
SCHEMBL15618391 0.84 HCAR3 (0.73) KMT2AALDH1A1MAPTRAB9ANPC1
SCHEMBL8886516 0.84 MAPT (0.72) KMT2AALDH1A1MAPTRAB9ANPC1
SCHEMBL15321361 0.83 HCAR3 (0.68) KMT2AALDH1A1MAPTRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240409533-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2024-12-12 — — US disclosed
CN-113874074-B HMOX1 inducers 米托布里奇公司 2024-11-01 — — CN disclosed
US-12071433-B2 HMOX1 inducers Astellas Engineered Small Molecules US, Incorporated (US) 2024-08-27 — — US disclosed
US-20240051952-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2024-02-15 — — US disclosed
US-20220177460-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2022-06-09 — — US disclosed
EP-3952990-A1 HMOX1 INDUCERS Mitobridge, Inc. (US) 2022-02-16 — — EP disclosed
CN-113874074-A HMOX1 inducers 米托布里奇公司 2021-12-31 — — CN disclosed
WO-2020210339-A1 HMOX1 INDUCERS MITOBRIDGE, INC. (US) 2020-10-15 — — WO disclosed
US-10766888-B1 HMOX1 inducers MITOBRIDGE INC. (US) 2020-09-08 — — US disclosed
EP-2594555-B1 HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR ASKA PHARM CO LTD (JP) 2018-03-07 — — EP disclosed
EP-2594555-A1 HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR ASKA Pharmaceutical Co., Ltd. (JP) 2013-05-22 — — EP disclosed
EP-2594555-A1 HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR ASKA Pharmaceutical Co., Ltd. (JP) 2013-05-22 — — EP disclosed
US-20130079306-A1 HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR ASKA PHARMACEUTICAL CO., LTD. (JP) 2013-03-28 — — US disclosed
US-20130079306-A1 HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR ASKA PHARMACEUTICAL CO., LTD. (JP) 2013-03-28 — — US disclosed
US-20130079306-A1 HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR ASKA PHARMACEUTICAL CO., LTD. (JP) 2013-03-28 — — US disclosed
WO-2012002527-A1 HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR あすか製薬株式会社 (JP) 2012-01-05 — — WO disclosed
US-20110312935-A1 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-12-22 — — US disclosed
EP-2334652-A1 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS Boehringer Ingelheim International GmbH (DE) 2011-06-22 — — EP disclosed
WO-2010034796-A1 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-04-01 — — WO disclosed
US-20090270435-A1 Spiroketone Acetyl-CoA Carboxylase Inhibitors CORBETT JEFFREY WAYNE 2009-10-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10766888-B1 HMOX1 inducers HMOX1, HMOX2, HMBS KMT2A 2901/4885ALDH1A1 332/4885MAPT 3846/4885
US-20110312935-A1 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents MAPRE2, MAPRE1, H1-4 KMT2A 1047/4885ALDH1A1 1202/4885MAPT 480/4885
US-20130079306-A1 HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR CDKN1A, SKP2, CCNI KMT2A 1012/4885ALDH1A1 1594/4885MAPT 4033/4885
US-20240409533-A1 HMOX1 INDUCERS HMOX1, HMOX2, HMBS KMT2A 2901/4885ALDH1A1 332/4885MAPT 3846/4885
US-12071433-B2 HMOX1 inducers HMOX1, HMOX2, HMBS KMT2A 3092/4885ALDH1A1 223/4885MAPT 3756/4885
US-20240051952-A1 HMOX1 INDUCERS HMOX1, HMOX2, QSOX1 KMT2A 4276/4885ALDH1A1 266/4885MAPT 3238/4885
US-20090270435-A1 Spiroketone Acetyl-CoA Carboxylase Inhibitors ACACA, PC, ACACB KMT2A 2243/4885ALDH1A1 212/4885MAPT 2999/4885
US-20220177460-A1 HMOX1 INDUCERS HMOX1, HMOX2, HMBS KMT2A 3092/4885ALDH1A1 223/4885MAPT 3756/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.