Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365269 | 0.90 | KARS1 (0.45) | KARS1ABL1BCRJAK2DHFR | |
| SCHEMBL19670263 | 0.90 | DHFR (0.37) | KARS1ABL1BCRJAK2DHFR | |
| SCHEMBL19670393 | 0.89 | ABL1 (0.42) | ABL1BCRJAK2CAMK2DTEK | |
| SCHEMBL19670389 | 0.88 | ROCK2 (0.35) | KARS1ABL1BCRJAK2CAMK2D | |
| SCHEMBL19365492 | 0.87 | MTOR (0.36) | KARS1SIRT2FAAH | |
| SCHEMBL19670252 | 0.87 | THRB (0.38) | KARS1SIRT2 | |
| SCHEMBL19670432 | 0.86 | TRPV3 (0.34) | ABL1BCRJAK2TEKCARM1 | |
| SCHEMBL19670428 | 0.85 | ABL1 (0.40) | ABL1FAAHGSK3BDYRK1AIRAK4 | |
| SCHEMBL16776055 | 0.84 | KARS1 (0.49) | KARS1ABL1BCRJAK2DHFR | |
| SCHEMBL19365562 | 0.84 | MTOR (0.41) | FAAHGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |