SCHEMBL19681252

SCHEMBL19681252

CC(=O)N1CCCC1C(=O)NCC(NC(=O)C1CCCN1C(C)=O)C(=O)NCCN

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
F2 P00734 3/20 0.43
P2RX7 Q99572 1/20 0.40
ITGB1 P05556 1/20 0.39
ITGA4 P13612 1/20 0.39
TNKS O95271 2/20 0.38
REN P00797 2/20 0.38
NPSR1 Q6W5P4 1/20 0.37
APLNR P35414 1/20 0.37
XIAP P98170 1/20 0.36
MMP1 P03956 1/20 0.36
MMP3 P08254 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19681207 0.86 MMP3 (0.46) F2ITGB1ITGA4NPSR1APLNR
SCHEMBL21166989 0.85 ACE (0.45) F2ITGB1ITGA4RENAPLNR
SCHEMBL19685305 0.85 P2RX7 (0.48) F2P2RX7TNKSNPSR1
SCHEMBL19677781 0.84 MEN1 (0.45) NPSR1APLNR
SCHEMBL21705595 0.83 F2 (0.46) F2P2RX7ITGB1ITGA4TNKS
SCHEMBL21350914 0.83 ITGB1 (0.42) F2P2RX7ITGB1ITGA4REN
SCHEMBL21166966 0.83 ITGB1 (0.44) F2ITGB1ITGA4RENAPLNR
SCHEMBL19681283 0.83 APLNR (0.44) F2P2RX7NPSR1APLNRMMP1
SCHEMBL21346666 0.82 REN (0.54) REN
SCHEMBL19681253 0.81 SIRT6 (0.52) F2NPSR1APLNRMMP1MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11707507-B2 Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analog, and a co-polyamino acid ADOCIA (FR) 2023-07-25 US disclosed
US-20200306346-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING HUMAN GLUCAGON AND A CO-POLYAMINO ACID ADOCIA (FR) 2020-10-01 US disclosed
US-20200046805-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING AMYLIN, AN AMYLIN RECEPTOR AGONIST OR AN AMYLIN ANALOG, AND A CO-POLYAMINO ACID ADOCIA (FR) 2020-02-13 US disclosed
US-10548952-B2 Injectable solution at pH7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5, a prandial insulin and/or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals ADOCIA (FR) 2020-02-04 US disclosed
US-10463717-B2 Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analog, and a co-polyamino acid ADOCIA (FR) 2019-11-05 US disclosed
US-20190274953-A1 PH 7 INJECTABLE SOLUTION COMPRISING AT LEAST ONE BASIC INSULIN WITH A PI COMPRISED FROM 5.8 TO 8.5 AND A CO-POLYAMINOACIDE BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS ADOCIA (FR) 2019-09-12 US disclosed
US-20190275108-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING AMYLIN, AN AMYLIN RECEPTOR AGONIST OR AN AMYLIN ANALOGUE AND A CO-POLYAMINO ACID ADOCIA (FR) 2019-09-12 US disclosed
US-20190275110-A1 COMPOSITIONS IN THE FORM OF AN INJECTALE AQUEOUS SOLUTION COMPRISING HUMAN GLUCAGON AND A CO-POLYAMINO ACID ADOCIA (FR) 2019-09-12 US disclosed
US-10383918-B2 Compositions in the form of an injectable aqueous solution comprising human glucagon and a statistical co-polyamino acid ADOCIA (FR) 2019-08-20 US disclosed
US-10383920-B2 Injectable solution at pH 7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals ADOCIA (FR) 2019-08-20 US disclosed
US-20180193421-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING AMYLIN, AN AMYLIN RECEPTOR AGONIST OR AN AMYLIN ANALOG, AND A CO-POLYAMINO ACID ADOCIA (FR) 2018-07-12 US disclosed
US-20170348394-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING HUMAN GLUCAGON AND A STATISTICAL CO-POLYAMINO ACID ADOCIA (FR) 2017-12-07 US disclosed
US-20170348395-A1 Compositions in the form of an injectable aqueous solution comprising human glucagon and a co-polyamino acid ADOCIA (FR) 2017-12-07 US disclosed
US-20170348423-A1 Injectable solution at pH 7 comprising at least one basal insulin the pl of which is from 5.8 to 8.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals ADOCIA (FR) 2017-12-07 US disclosed
US-20170348396-A1 Injectable solution at pH7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5, a prandial insulin and/or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals ADOCIA (FR) 2017-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190275108-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING AMYLIN, AN AMYLIN RECEPTOR AGONIST OR AN AMYLIN ANALOGUE AND A CO-POLYAMINO ACID IAPP, GPR119, GLP1R F2 2492/4885P2RX7 519/4885ITGB1 3012/4885
US-20180193421-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING AMYLIN, AN AMYLIN RECEPTOR AGONIST OR AN AMYLIN ANALOG, AND A CO-POLYAMINO ACID IAPP, GPR119, GIPR F2 2618/4885P2RX7 573/4885ITGB1 3307/4885
US-10463717-B2 Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analog, and a co-polyamino acid IAPP, GPR119, GIPR F2 2863/4885P2RX7 446/4885ITGB1 3317/4885
US-20200306346-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING HUMAN GLUCAGON AND A CO-POLYAMINO ACID GCG, GLP1R, GCGR F2 464/4885P2RX7 1969/4885ITGB1 4390/4885
US-20200046805-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING AMYLIN, AN AMYLIN RECEPTOR AGONIST OR AN AMYLIN ANALOG, AND A CO-POLYAMINO ACID IAPP, INSR, GLP1R F2 812/4885P2RX7 870/4885ITGB1 3493/4885
US-20170348423-A1 Injectable solution at pH 7 comprising at least one basal insulin the pl of which is from 5.8 to 8.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals IAPP, IDE, INSR F2 937/4885P2RX7 2698/4885ITGB1 2716/4885
US-20170348394-A1 COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING HUMAN GLUCAGON AND A STATISTICAL CO-POLYAMINO ACID GCG, GLP1R, IAPP F2 317/4885P2RX7 2375/4885ITGB1 3569/4885
US-10383918-B2 Compositions in the form of an injectable aqueous solution comprising human glucagon and a statistical co-polyamino acid GCG, GLP1R, IAPP F2 317/4885P2RX7 2375/4885ITGB1 3569/4885
US-20190275110-A1 COMPOSITIONS IN THE FORM OF AN INJECTALE AQUEOUS SOLUTION COMPRISING HUMAN GLUCAGON AND A CO-POLYAMINO ACID GCG, GLP1R, IAPP F2 305/4885P2RX7 2322/4885ITGB1 4124/4885
US-20170348395-A1 Compositions in the form of an injectable aqueous solution comprising human glucagon and a co-polyamino acid GCG, GLP1R, IAPP F2 580/4885P2RX7 2232/4885ITGB1 4242/4885
US-11707507-B2 Compositions in the form of an injectable aqueous solution comprising amylin, an amylin receptor agonist or an amylin analog, and a co-polyamino acid IAPP, INSR, GLP1R F2 812/4885P2RX7 870/4885ITGB1 3493/4885
US-10383920-B2 Injectable solution at pH 7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals IAPP, IDE, INSR F2 663/4885P2RX7 2937/4885ITGB1 2742/4885
US-20170348396-A1 Injectable solution at pH7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5, a prandial insulin and/or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals IAPP, F7, GIPR F2 636/4885P2RX7 1732/4885ITGB1 4480/4885
US-20190274953-A1 PH 7 INJECTABLE SOLUTION COMPRISING AT LEAST ONE BASIC INSULIN WITH A PI COMPRISED FROM 5.8 TO 8.5 AND A CO-POLYAMINOACIDE BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS GPR119, INSR, GCG F2 1977/4885P2RX7 1394/4885ITGB1 3828/4885
US-10548952-B2 Injectable solution at pH7 comprising at least one basal insulin the pI of which is from 5.8 to 8.5, a prandial insulin and/or a gastrointestinal hormone, and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals IAPP, F7, GIPR F2 636/4885P2RX7 1732/4885ITGB1 4480/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.