Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22174075 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL19683938 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL12747580 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL278527 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL19444546 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL13291136 | 1.00 | ALDH1A1 (0.61) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL13534106 | 0.86 | POLB (0.52) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL13239534 | 0.86 | POLB (0.52) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL793891 | 0.86 | POLB (0.52) | ALDH1A1TDP1MEN1KMT2ARAB9A | |
| SCHEMBL14727215 | 0.86 | ALDH1A1 (0.52) | ALDH1A1TDP1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230068959-A1 | BRANCHED MULTI-FUNCTIONAL MACROMONOMERS AND RELATED POLYMERS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-03-02 | — | — | US | disclosed |
| US-20210284664-A1 | DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-09-16 | — | — | US | disclosed |
| US-20210220391-A1 | PROTEOLYSIS TARGETING CHIMERIC MOLECULES (PROTACS) WITH FUNCTIONAL HANDLES AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-07-22 | — | — | US | disclosed |
| WO-2021076821-A2 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-04-22 | — | — | WO | disclosed |
| WO-2020037236-A1 | DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2020-02-20 | — | — | WO | disclosed |
| WO-2017214337-A1 | DRUG DELIVERY POLYMERS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-12-14 | — | — | WO | disclosed |
| US-20170348431-A1 | DRUG DELIVERY POLYMERS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348431-A1 | DRUG DELIVERY POLYMERS AND USES THEREOF | BRAP, PAICS, BRPF1 | ALDH1A1 2807/4885TDP1 3223/4885MEN1 915/4885 |
| US-20210284664-A1 | DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF | SI, ILK, PCNA | ALDH1A1 2604/4885TDP1 3212/4885MEN1 2734/4885 |
| US-20210220391-A1 | PROTEOLYSIS TARGETING CHIMERIC MOLECULES (PROTACS) WITH FUNCTIONAL HANDLES AND USES THEREOF | CRBN, PSMA6, PSMA3 | ALDH1A1 3287/4885TDP1 2968/4885MEN1 3868/4885 |
| US-20230068959-A1 | BRANCHED MULTI-FUNCTIONAL MACROMONOMERS AND RELATED POLYMERS AND USES THEREOF | MSN, CAD, NEDD8 | ALDH1A1 469/4885TDP1 2521/4885MEN1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.