Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY6 | Q15077 | 2/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LTA | P01374 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30298625 | 1.00 | P2RY6 (0.37) | P2RY6MIFNAAACTNNB1WNT3A | |
| SCHEMBL10850783 | 0.89 | P2RY6 (0.37) | P2RY6MIFPNMTKIF11KDM4E | |
| SCHEMBL11114110 | 0.82 | P2RY6 (0.33) | P2RY6MIFPNMTKDM4EUSP2 | |
| SCHEMBL11003249 | 0.82 | MAPK1 (0.43) | CTNNB1WNT3ANOTUMPIK3CAPIK3CG | |
| SCHEMBL11000954 | 0.79 | PNMT (0.34) | P2RY6MIFPNMTKDM4EUSP2 | |
| SCHEMBL11000092 | 0.78 | P2RY6 (0.32) | P2RY6MIFPNMTKDM4EUSP2 | |
| SCHEMBL9428400 | 0.77 | P2RY6 (0.37) | P2RY6MIFPNMTKDM4EUSP2 | |
| SCHEMBL10451237 | 0.71 | MAPK1 (0.43) | KIF11CYP3A4TDP1 | |
| SCHEMBL276124 | 0.70 | ADRA2A (0.53) | P2RY6MIFPNMTNPC1RAB9A | |
| SCHEMBL1019410 | 0.70 | HTR3E (0.53) | P2RY6MIFPNMTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259267-B2 | Difluorobenzo-1,3-dioxoles | LANXESS DEUTSCHLAND GMBH (DE) | 2007-08-21 | — | — | US | claimed |
| US-20050272811-A1 | Difluorobenzo-1,3-dioxoles | LANXESS DEUTSCHLAND GMBH (DE) | 2005-12-08 | — | — | US | claimed |
| EP-1595875-A2 | Isothiocyanato-2,2-difluoro-1,3-benzodioxoles | Lanxess Deutschland GmbH (DE) | 2005-11-16 | — | — | EP | claimed |
| EP-4139286-B1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AG (DE) | 2025-02-26 | — | — | EP | disclosed |
| US-12018021-B2 | Thiophene derivatives for the treatment of disorders caused by IgE | UCB Biopharma SRL (BE) | 2024-06-25 | — | — | US | disclosed |
| US-11964953-B2 | Substituted aminothiazoles as DGKzeta inhibitors for immune activation | BAYER AKTIENGESELLSCHAFT (DE) | 2024-04-23 | — | — | US | disclosed |
| WO-2023158862-A2 | STIMULATOR OF INTERFERON GENES (STING) MODULATORS, AND COMPOSITIONS AND METHODS THEREOF | GEODE THERAPEUTICS INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| US-20230167078-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2023-06-01 | — | — | US | disclosed |
| US-20230139936-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2023-05-04 | — | — | US | disclosed |
| CN-112566910-A | Thiophene derivatives for the treatment of IgE induced diseases | UCB生物制药有限责任公司 | 2021-03-26 | — | — | CN | disclosed |
| EP-1595875-B1 | Process for the preparation of isothiocyanato-2,2-difluoro-1,3-benzodioxoles | SALTIGO GMBH (DE) | 2011-06-22 | — | — | EP | disclosed |
| CN-100569766-C | The difluoro phendioxin, the 3-dioxole | LANXESS DEUTSCHLAND GMBH (DE) | 2009-12-16 | — | — | CN | disclosed |
| US-7259267-B2 | Difluorobenzo-1,3-dioxoles | LANXESS DEUTSCHLAND GMBH (DE) | 2007-08-21 | — | — | US | disclosed |
| US-20050272811-A1 | Difluorobenzo-1,3-dioxoles | LANXESS DEUTSCHLAND GMBH (DE) | 2005-12-08 | — | — | US | disclosed |
| EP-1595875-A2 | Isothiocyanato-2,2-difluoro-1,3-benzodioxoles | Lanxess Deutschland GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| CN-1696126-A | Process for the preparation of 5-bromo-2,2-difluorobenzo-(1,3)-dioxoles | LANXESS DEUTSCHLAND GMBH (DE) | 2005-11-16 | — | — | CN | disclosed |
| US-4536587-A | APPLYING DIRECTLY TO HABITAT | BAYER AKTIENGESELLSCHAFT (DE) | 1985-08-20 | — | — | US | disclosed |
| EP-0042533-B1 | SUBSTITUTED BENZOYL(THIO) UREAS, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PESTICIDES | BAYER AG (DE) | 1984-03-14 | — | — | EP | disclosed |
| EP-0042533-A1 | Substituted benzoyl(thio) ureas, processes for their production and their use as pesticides | BAYER AG (DE) | 1981-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230139936-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | DGKZ, DGKA, DGKG | P2RY6 1187/4885MIF 3660/4885NAAA 1783/4885 |
| US-20230167078-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | DGKZ, DGKA, DGKG | P2RY6 1187/4885MIF 3660/4885NAAA 1783/4885 |
| US-11964953-B2 | Substituted aminothiazoles as DGKzeta inhibitors for immune activation | DGKZ, DGKA, DGKG | P2RY6 1187/4885MIF 3660/4885NAAA 1783/4885 |
| US-20050272811-A1 | Difluorobenzo-1,3-dioxoles | BROX, DDT, CAT | P2RY6 2945/4885MIF 1924/4885NAAA 2940/4885 |
| US-12018021-B2 | Thiophene derivatives for the treatment of disorders caused by IgE | TSLP, CYSLTR1, CYSLTR2 | P2RY6 887/4885MIF 1146/4885NAAA 3429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.