SCHEMBL197338

SCHEMBL197338

COC(=O)C(F)(F)C(=O)CF

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
DGAT1 O75907 1/20 0.33
MAPT P10636 1/20 0.32
GAA P10253 1/20 0.31
TSHR P16473 1/20 0.31
KCNN4 O15554 1/20 0.30
CTRB1 P17538 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4314333 0.81 ALDH1A1 (0.33) ALDH1A1DGAT1GAATSHRKCNN4
SCHEMBL8355251 0.79 KCNN4 (0.33) ALDH1A1DGAT1MAPTGAAKCNN4
SCHEMBL2580230 0.79 DGAT1 (0.42) ALDH1A1DGAT1MAPTGAATSHR
SCHEMBL12158579 0.78
SCHEMBL457731 0.77 PKM (0.40) ALDH1A1MAPTGAA
SCHEMBL8355247 0.77 ALDH1A1 (0.34) ALDH1A1DGAT1MAPT
Water SCHEMBL10546251 0.76 MEN1 (0.40) ALDH1A1MAPTGAA
SCHEMBL6323017 0.76 TSHR (0.36) TSHR
SCHEMBL7406644 0.76 PKM (0.39) ALDH1A1MAPTGAA
SCHEMBL6320646 0.74 CES2 (0.35) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025110550-A1 COMPLEX FOR GENE DELIVERY 전남대학교산학협력단 2025-05-30 WO claimed
CN-116632340-A Lithium ion electrolyte for inhibiting flatulence, preparation method thereof and electrochemical device 湖南法恩莱特新能源科技有限公司 2023-08-22 CN claimed
EP-0135491-B1 HERBICIDAL 2,6-BIS-FLUOROMETHYL-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID ESTERS MONSANTO COMPANY (US) 1989-01-25 EP claimed
EP-0135491-A1 Herbicidal 2,6-bis-fluoromethyl-dihydropyridine-3,5-dicarboxylic acid esters MONSANTO COMPANY (US) 1985-03-27 EP claimed
JP-9227440-A None JP disclosed
US-12544382-B2 2, 4, 6-tri-substituted pyrimidine compound as ATR kinase inhibitor BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) 2026-02-10 US disclosed
WO-2025110550-A1 COMPLEX FOR GENE DELIVERY 전남대학교산학협력단 2025-05-30 WO disclosed
CN-118908902-A Preparation method of 3-trifluoromethyl-2-pyrazinecarboxylic acid ester compound 山东京博农化科技股份有限公司 2024-11-08 CN disclosed
CN-118619944-A 2,4, 6-Trisubstituted pyrimidine compounds as ATR kinase inhibitors 北京泰德制药股份有限公司 2024-09-10 CN disclosed
US-20240043593-A1 Fluorine-Containing Polymer CENTRAL GLASS COMPANY, LIMITED (JP) 2024-02-08 US disclosed
CN-116632340-A Lithium ion electrolyte for inhibiting flatulence, preparation method thereof and electrochemical device 湖南法恩莱特新能源科技有限公司 2023-08-22 CN disclosed
US-20220378799-A1 2, 4, 6-TRI-SUBSTITUTED PYRIMIDINE COMPOUND AS ATR KINASE INHIBITOR BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) 2022-12-01 US disclosed
US-4826532-A HERBICIDES MONSANTO COMPANY (US) 1989-05-02 US disclosed
EP-0135491-B1 HERBICIDAL 2,6-BIS-FLUOROMETHYL-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID ESTERS MONSANTO COMPANY (US) 1989-01-25 EP disclosed
EP-0278945-A2 Substituted 2,6-substituted pyridine compounds Monsanto Company (US) 1988-08-17 EP disclosed
EP-0278944-A1 Substituted 2,6-substituted pyridine compounds Monsanto Company (US) 1988-08-17 EP disclosed
US-4692184-A HERBICIDES MONSANTO COMPANY (US) 1987-09-08 US disclosed
EP-0135491-A1 Herbicidal 2,6-bis-fluoromethyl-dihydropyridine-3,5-dicarboxylic acid esters MONSANTO COMPANY (US) 1985-03-27 EP disclosed
EP-0133612-A2 Substituted 2,6-substituted pyridine compounds MONSANTO COMPANY (US) 1985-02-27 EP disclosed
US-4042603-A SUBSTITUTED DIBENZOFURAN OR 9-FLUORENONE FROM A DIPHENYL ETHER OR BENZOPHENONE UBE INDUSTRIES, LTD. (JA) 1977-08-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12544382-B2 2, 4, 6-tri-substituted pyrimidine compound as ATR kinase inhibitor ATR, CHEK1, CHEK2 ALDH1A1 3420/4885DGAT1 3800/4885MAPT 3379/4885
US-20220378799-A1 2, 4, 6-TRI-SUBSTITUTED PYRIMIDINE COMPOUND AS ATR KINASE INHIBITOR ATR, CHEK2, CHEK1 ALDH1A1 4026/4885DGAT1 2645/4885MAPT 1910/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.