Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19857016 | 0.93 | HCRTR2 (0.36) | HCRTR2HCRTR1KMT2AMEN1 | |
| SCHEMBL19856941 | 0.91 | TNF (0.37) | RAB9AKMT2AMEN1AVPR2AVPR1A | |
| SCHEMBL19856929 | 0.89 | CCR2 (0.35) | HCRTR2HCRTR1TSHRKDM4EALOX15 | |
| SCHEMBL19856975 | 0.89 | SMN1; SMN2 (0.34) | NPC1RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL19856992 | 0.87 | CCR2 (0.34) | MGLLALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL19856933 | 0.87 | HPGD (0.36) | HCRTR2HCRTR1NPC1RAB9AALDH1A1 | |
| SCHEMBL19856957 | 0.85 | AVPR1A (0.34) | AVPR2AVPR1A | |
| SCHEMBL19856981 | 0.84 | SIRT3 (0.38) | NPC1RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL19856993 | 0.84 | PLA2G10 (0.38) | HCRTR2HCRTR1 | |
| SCHEMBL19856960 | 0.83 | PLA2G10 (0.38) | MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |