Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 5/20 | 0.34 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.34 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856941 | 0.92 | TNF (0.37) | AVPR1AAVPR2CCR2 | |
| SCHEMBL19856933 | 0.91 | HPGD (0.36) | AVPR1AAVPR2CCR2HSD11B1 | |
| SCHEMBL19856992 | 0.90 | CCR2 (0.34) | CCR2HSD11B1 | |
| SCHEMBL19856991 | 0.88 | SLC6A7 (0.37) | SLC6A7DPP4DPP8DPP9DPP7 | |
| SCHEMBL19856993 | 0.88 | PLA2G10 (0.38) | CCR2 | |
| SCHEMBL19856975 | 0.88 | SMN1; SMN2 (0.34) | CCR2HSD11B1 | |
| SCHEMBL19856929 | 0.87 | CCR2 (0.35) | CCR2HSD11B1 | |
| SCHEMBL19856960 | 0.84 | PLA2G10 (0.38) | CCR2HSD11B1 | |
| SCHEMBL19857030 | 0.83 | PLA2G10 (0.38) | CCR2 | |
| SCHEMBL19856907 | 0.82 | HCRTR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |