Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856933 | 0.94 | HPGD (0.36) | TNFNOD2NOD1CCR2AVPR2 | |
| SCHEMBL19856929 | 0.93 | CCR2 (0.35) | CCR2F10 | |
| SCHEMBL19856992 | 0.93 | CCR2 (0.34) | CCR2KMT2AMEN1P2RX7CRHBP | |
| SCHEMBL19856957 | 0.92 | AVPR1A (0.34) | CCR2AVPR2AVPR1A | |
| SCHEMBL19856993 | 0.91 | PLA2G10 (0.38) | CCR2 | |
| SCHEMBL19856975 | 0.91 | SMN1; SMN2 (0.34) | CCR2F10KMT2AMEN1POLB | |
| SCHEMBL19856910 | 0.91 | HCRTR2 (0.37) | KMT2AMEN1AVPR2AVPR1ARAB9A | |
| SCHEMBL19857030 | 0.86 | PLA2G10 (0.38) | CCR2KMT2ACRHR2 | |
| SCHEMBL19856960 | 0.86 | PLA2G10 (0.38) | NOD2NOD1CCR2F10 | |
| SCHEMBL19856966 | 0.85 | CYP3A4 (0.34) | CCR2F10P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |