Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CPS1 | P31327 | 3/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856941 | 0.91 | TNF (0.37) | POLBMEN1KMT2ACCR2RAB9A | |
| SCHEMBL19856933 | 0.90 | HPGD (0.36) | SMN1; SMN2CCR2NPC1RAB9AALDH1A1 | |
| SCHEMBL19856992 | 0.89 | CCR2 (0.34) | MEN1KMT2ACCR2KDM4EALDH1A1 | |
| SCHEMBL19856910 | 0.89 | HCRTR2 (0.37) | SMN1; SMN2BTKMEN1KMT2AFLT1 | |
| SCHEMBL19856957 | 0.88 | AVPR1A (0.34) | CCR2HSD11B1 | |
| SCHEMBL19856981 | 0.88 | SIRT3 (0.38) | SMN1; SMN2LMNAMEN1KMT2ADRD2 | |
| SCHEMBL19856993 | 0.87 | PLA2G10 (0.38) | CCR2PLA2G10 | |
| SCHEMBL19856929 | 0.86 | CCR2 (0.35) | LMNACCR2KDM4EF10TP53 | |
| SCHEMBL19857030 | 0.82 | PLA2G10 (0.38) | KMT2ACCR2PLA2G10 | |
| SCHEMBL19856960 | 0.82 | PLA2G10 (0.38) | KCNH2CCR2F10PLA2G10HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |