Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.30 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.30 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856941 | 0.94 | TNF (0.37) | CCR2NOD2NOD1RAB9ATNF | |
| SCHEMBL19856992 | 0.92 | CCR2 (0.34) | ALDH1A1CCR2SPRHSD11B1 | |
| SCHEMBL19856957 | 0.91 | AVPR1A (0.34) | CCR2AVPR2AVPR1AHSD11B1 | |
| SCHEMBL19856907 | 0.91 | HCRTR1 (0.33) | NOD2NOD1HCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL19856975 | 0.90 | SMN1; SMN2 (0.34) | ALDH1A1CCR2NPC1RAB9APKM | |
| SCHEMBL19856993 | 0.90 | PLA2G10 (0.38) | CCR2HCRTR1HCRTR2 | |
| SCHEMBL19856929 | 0.89 | CCR2 (0.35) | CCR2HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL19856988 | 0.89 | NOD2 (0.41) | ALDH1A1NOD2NOD1NPC1RAB9A | |
| SCHEMBL19857030 | 0.85 | PLA2G10 (0.38) | CCR2HCRTR1HCRTR2 | |
| SCHEMBL19856960 | 0.85 | PLA2G10 (0.38) | CCR2NOD2NOD1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |