Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14841644 | 0.74 | NLRP3 (0.34) | NLRP3 | |
| Trifluoroacetic Acid SCHEMBL9251412 | 0.72 | CRHBP (0.49) | CRHBPCRHR2 | |
| SCHEMBL15335066 | 0.71 | CYP3A4 (0.35) | ESR1ESR2EPHX1 | |
| SCHEMBL3476909 | 0.71 | CRHBP (0.38) | CRHBPCRHR2 | |
| SCHEMBL23075157 | 0.70 | SMN1; SMN2 (0.34) | ESR1ESR2EPHX1 | |
| SCHEMBL31481597 | 0.69 | ALDH1A1 (0.44) | ESR2EPHX1 | |
| SCHEMBL1993249 | 0.69 | ALDH1A1 (0.41) | NLRP3 | |
| SCHEMBL9347128 | 0.69 | L3MBTL1 (0.39) | NLRP3 | |
| SCHEMBL31065659 | 0.69 | CASP3 (0.37) | NLRP3 | |
| Nibrozetone SCHEMBL2249018 | 0.69 | NLRP3 (0.47) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178698-B2 | Methods of synthesizing cyclic nitro compounds | ALLIANT TECHSYSTEMS INC. (US) | 2012-05-15 | — | — | US | claimed |
| US-20110130572-A1 | METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS | ALLIANT TECHSYSTEMS INC. (US) | 2011-06-02 | — | — | US | claimed |
| US-20090093644-A1 | METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS | ALLIANT TECHSYSTEMS INC. (US) | 2009-04-09 | — | — | US | claimed |
| US-10149832-B2 | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof | EPICENTRX, INC. (US) | 2018-12-11 | — | — | US | disclosed |
| US-9226915-B2 | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof | EPICENTRX, INC. (US) | 2016-01-05 | — | — | US | disclosed |
| US-8927527-B2 | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof | EPICENTRX, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| EP-1924253-B1 | CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF | ALLIANT TECHSYSTEMS INC (US) | 2014-12-10 | — | — | EP | disclosed |
| US-8299053-B2 | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof | RADIORX, INC. (US) | 2012-10-30 | — | — | US | disclosed |
| US-8178698-B2 | Methods of synthesizing cyclic nitro compounds | ALLIANT TECHSYSTEMS INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20110130572-A1 | METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS | ALLIANT TECHSYSTEMS INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-7507842-B2 | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof | RADIORX, INC. (US) | 2009-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130572-A1 | METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS | NOS2, NOS1, NOS3 | ESR1 3419/4885ESR2 2692/4885NLRP3 965/4885 |
| US-20090093644-A1 | METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS | NOS2, NOS1, NOS3 | ESR1 3419/4885ESR2 2692/4885NLRP3 965/4885 |
| US-10149832-B2 | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof | NOS1, NOS2, NOS3 | ESR1 3231/4885ESR2 2609/4885NLRP3 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.