Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.50 |
| ▸ | HTR1B | P28222 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19983845 | 0.88 | TBXAS1 (0.44) | HTR1DHTR1BHTR1ACHRNB2CHRNA7 | |
| SCHEMBL19984000 | 0.85 | HTR2A (0.46) | HTR1DHTR1ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL19984119 | 0.84 | GPR84 (0.53) | HTR1ACHRNB2CHRNA7CHRNA4GPR84 | |
| SCHEMBL19983831 | 0.82 | HTR2A (0.49) | ALDH1A1MEN1GAAMAPTKMT2A | |
| SCHEMBL19984216 | 0.80 | GPR84 (0.48) | HTR1DHTR1BHTR1ACHRNB2CHRNA7 | |
| SCHEMBL19983833 | 0.79 | SCN9A (0.44) | HTR1ACHRNB2CHRNA7CHRNA4ALDH1A1 | |
| SCHEMBL19983847 | 0.78 | TBXAS1 (0.42) | HTR1DHTR1BHTR1ACHRNB2CHRNA7 | |
| SCHEMBL19984002 | 0.78 | CHRNB2 (0.51) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL19983734 | 0.78 | GPR84 (0.46) | HTR1ACHRNB2CHRNA7CHRNA4MAPT | |
| SCHEMBL19984180 | 0.78 | HTR2A (0.47) | CHRNB2CHRNA7CHRNA4GPR84HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |