Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19983953 | 0.79 | GPR84 (0.43) | GPR84CHRNB2CHRNA7CHRNA4TDO2 | |
| SCHEMBL19983776 | 0.77 | CHRNB2 (0.42) | DYRK1AGPR84CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL31415127 | 0.76 | GPR84 (0.72) | GPR84CHRNB2CHRNA7CHRNA4TDO2 | |
| SCHEMBL19984200 | 0.76 | ROCK2 (0.41) | GPR84CHRNB2CHRNA7CHRNA4TDO2 | |
| SCHEMBL19983923 | 0.74 | GPR84 (0.51) | GPR84CHRNB2CHRNA7CHRNA4HTR2A | |
| SCHEMBL19984283 | 0.73 | HTR2A (0.47) | GPR84CHRNB2CHRNA7CHRNA4TDO2 | |
| SCHEMBL19983810 | 0.73 | ALKBH5 (0.39) | GPR84CHRNB2CHRNA7CHRNA4MAPK1 | |
| SCHEMBL3281375 | 0.71 | HTR2A (0.61) | MAPTGPR84CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL15897700 | 0.70 | CHRNB2 (0.72) | GPR84CHRNB2CHRNA7CHRNA4IDO1 | |
| SCHEMBL19983863 | 0.70 | GPR84 (0.38) | GPR84CHRNB2CHRNA7CHRNA4TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |