Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005893 | 0.95 | SCD (0.34) | MAPK14SCDSCD5MAPK1MEN1 | |
| SCHEMBL2005962 | 0.92 | L3MBTL1 (0.35) | MAPK14SCDSCD5MAPK1LMNA | |
| SCHEMBL1999358 | 0.92 | FAAH (0.41) | FAAHMAPK14SCDSCD5MEN1 | |
| SCHEMBL2002685 | 0.91 | PLA2G2A (0.37) | MAPK1MEN1KMT2APTGDR2CYP2C9 | |
| SCHEMBL2006492 | 0.90 | GRM5 (0.35) | FAAHMEN1KMT2ACYP2C9CYP3A4 | |
| SCHEMBL2005502 | 0.90 | LMNA (0.38) | MAPK14SCDSCD5MEN1KMT2A | |
| SCHEMBL2001504 | 0.90 | FAAH (0.35) | FAAHMAPK14MAPK1MEN1KMT2A | |
| SCHEMBL2004879 | 0.90 | ALOX5AP (0.33) | SCDSCD5CYP2C9CYP3A4EIF4EBP1 | |
| SCHEMBL2008461 | 0.89 | RET (0.36) | FAAHMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL2005516 | 0.88 | FAAH (0.33) | FAAHMAPK14SCDSCD5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |