Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | SLC26A6 | Q9BXS9 | 11/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20161291 | 0.82 | LMNA (0.39) | SMN1; SMN2SLC26A6LMNAMEN1KMT2A | |
| SCHEMBL20161209 | 0.80 | AURKA (0.40) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL20149081 | 0.79 | KDM4E (0.38) | SMN1; SMN2LMNAMEN1KMT2ANPC1 | |
| SCHEMBL20161113 | 0.77 | RPS6KB1 (0.41) | LMNAMEN1KMT2AHTTNPC1 | |
| SCHEMBL20161518 | 0.75 | CASP6 (0.43) | SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL20161268 | 0.75 | ACHE (0.36) | LMNAMEN1KMT2A | |
| SCHEMBL20161118 | 0.74 | CSNK1D (0.46) | SMN1; SMN2HTT | |
| SCHEMBL22874060 | 0.73 | AURKA (0.43) | SMN1; SMN2SLC26A6LMNAMEN1KMT2A | |
| SCHEMBL20161340 | 0.73 | CYP11B1 (0.35) | SMN1; SMN2LMNAMEN1KMT2AHTT | |
| SCHEMBL20161335 | 0.72 | KDM4E (0.37) | SMN1; SMN2LMNAMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |