Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20161340 | 0.83 | CYP11B1 (0.35) | KDM4EAURKARPS6KB1LMNAMEN1 | |
| SCHEMBL20161113 | 0.80 | RPS6KB1 (0.41) | KDM4EAURKARPS6KB1CASP6LMNA | |
| SCHEMBL20161209 | 0.80 | AURKA (0.40) | KDM4EAURKARPS6KB1CASP6LMNA | |
| SCHEMBL20149081 | 0.78 | KDM4E (0.38) | KDM4EAURKARPS6KB1CASP6LMNA | |
| SCHEMBL20161291 | 0.77 | LMNA (0.39) | KDM4EAURKARPS6KB1CASP6LMNA | |
| SCHEMBL20161301 | 0.75 | SMN1; SMN2 (0.55) | LMNAMEN1KMT2A | |
| SCHEMBL20161118 | 0.75 | CSNK1D (0.46) | ACHEKDM4EALDH1A1 | |
| SCHEMBL20161518 | 0.74 | CASP6 (0.43) | KDM4EAURKARPS6KB1CASP6LMNA | |
| SCHEMBL20161335 | 0.73 | KDM4E (0.37) | KDM4EAURKARPS6KB1LMNAALDH1A1 | |
| SCHEMBL20161336 | 0.67 | ALDH1A1 (0.39) | KDM4EAURKARPS6KB1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |