Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 4/20 | 0.46 |
| ▸ | STAT6 | P42226 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20161209 | 0.80 | AURKA (0.40) | KDM4EALDH1A1MAPTGAAPOLB | |
| SCHEMBL20161096 | 0.80 | STAT6 (0.47) | CSNK1DSTAT6KDM4EALDH1A1MAPT | |
| SCHEMBL20149081 | 0.79 | KDM4E (0.38) | KDM4EGAAPOLBSMN1; SMN2PDE5A | |
| SCHEMBL20161291 | 0.78 | LMNA (0.39) | KDM4EALDH1A1GAAPOLBSMN1; SMN2 | |
| SCHEMBL20161113 | 0.77 | RPS6KB1 (0.41) | KDM4EALDH1A1MAPTGAACCNE1 | |
| SCHEMBL20161335 | 0.76 | KDM4E (0.37) | STAT6KDM4EALDH1A1MAPTGAA | |
| SCHEMBL20161518 | 0.75 | CASP6 (0.43) | KDM4EALDH1A1SMN1; SMN2CCNE1CDK2 | |
| SCHEMBL20161340 | 0.75 | CYP11B1 (0.35) | KDM4EMAPTMAPK1POLBSMN1; SMN2 | |
| SCHEMBL20161268 | 0.75 | ACHE (0.36) | KDM4EALDH1A1ACHE | |
| SCHEMBL20161301 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |