Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12102424 | 0.82 | HDAC6 (0.71) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL15690552 | 0.81 | HDAC6 (0.65) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL229039 | 0.81 | HDAC6 (0.82) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL29988092 | 0.81 | HDAC6 (0.82) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL2019815 | 0.80 | ALDH1A1 (0.43) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL15119006 | 0.80 | HDAC6 (0.60) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL28538533 | 0.79 | HDAC6 (0.75) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL16544776 | 0.78 | HDAC6 (0.68) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL16866945 | 0.78 | HDAC6 (0.56) | HDAC6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL24755550 | 0.77 | HDAC6 (0.69) | HDAC6HDAC1HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468716-B1 | Process for producing bendamustine alkyl esters, bendamustine and derivatives of same | HERAEUS DEUTSCHLAND GMBH & CO KG (DE) | 2017-07-19 | — | — | EP | disclosed |
| EP-2834215-B1 | PROCESS FOR MAKING BENDAMUSTINE | SYNTHON BV (NL) | 2017-04-26 | — | — | EP | disclosed |
| US-9376394-B2 | Preparation of bendamustine and its salts | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-06-28 | — | — | US | disclosed |
| US-20150175554-A1 | Highly pure bendamustine hydrochloride monohydrate | SHILPA MEDICARE LTD (IN) | 2015-06-25 | — | — | US | disclosed |
| US-20130217888-A1 | PROCESS FOR PREPARING BENDAMUS TINE HYDROCHLORIDE MONOHYDRATE | SHAILPA MEDICARE LIMITED (IN) | 2013-08-22 | — | — | US | disclosed |
| US-8481751-B2 | Process for the production of bendamustine alkyl ester, bendamustine, and derivatives thereof | HERAEUS PRECIOUS METALS GMBH & CO. KG (DE) | 2013-07-09 | — | — | US | disclosed |
| US-20130158273-A1 | PREPARATION OF BENDAMUSTINE AND ITS SALTS | DR. REDDY'S LABORATORIES, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| EP-2516404-A2 | PREPARATION OF BENDAMUSTINE AND ITS SALTS | Dr. Reddy's Laboratories Ltd. (IN) | 2012-10-31 | — | — | EP | disclosed |
| US-20120165543-A1 | PROCESS FOR THE PRODUCTION OF BENDAMUSTINE ALKYL ESTER, BENDAMUSTINE, AND DERIVATIVES THEREOF | HERAEUS PRECIOUS METALS GMBH & CO. KG (DE) | 2012-06-28 | — | — | US | disclosed |
| EP-2468716-A1 | Process for producing bendamustine alkyl esters, bendamustine and derivatives of same | Heraeus Precious Metals GmbH & Co. KG (DE) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011079193-A2 | PREPARATION OF BENDAMUSTINE AND ITS SALTS | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158273-A1 | PREPARATION OF BENDAMUSTINE AND ITS SALTS | FOLR1, FOLR2, FLT3 | HDAC6 2271/4885HDAC1 4097/4885HDAC8 3295/4885 |
| US-20120165543-A1 | PROCESS FOR THE PRODUCTION OF BENDAMUSTINE ALKYL ESTER, BENDAMUSTINE, AND DERIVATIVES THEREOF | OTC, OAT, BCKDK | HDAC6 1763/4885HDAC1 2804/4885HDAC8 2776/4885 |
| US-20130217888-A1 | PROCESS FOR PREPARING BENDAMUS TINE HYDROCHLORIDE MONOHYDRATE | FLT3, TYMP, SBDS | HDAC6 3562/4885HDAC1 4483/4885HDAC8 4457/4885 |
| US-20150175554-A1 | Highly pure bendamustine hydrochloride monohydrate | BHMT, FOLR2, SMCHD1 | HDAC6 3846/4885HDAC1 4015/4885HDAC8 4560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.